Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 4793818..4795401 Replicon chromosome
Accession NZ_CP104863
Organism Stenotrophomonas maltophilia strain CW002SM

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N0O74_RS22335 Protein ID WP_049419249.1
Coordinates 4794079..4795401 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N0O74_RS22330 Protein ID WP_005407534.1
Coordinates 4793818..4794075 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0O74_RS22320 (N0O74_22320) 4789163..4789798 - 636 WP_005407536.1 hypothetical protein -
N0O74_RS22325 (N0O74_22325) 4789970..4793656 + 3687 WP_100443437.1 indolepyruvate ferredoxin oxidoreductase family protein -
N0O74_RS22330 (N0O74_22330) 4793818..4794075 + 258 WP_005407534.1 helix-turn-helix transcriptional regulator Antitoxin
N0O74_RS22335 (N0O74_22335) 4794079..4795401 + 1323 WP_049419249.1 type II toxin-antitoxin system HipA family toxin Toxin
N0O74_RS22340 (N0O74_22340) 4795402..4796016 - 615 WP_012478716.1 DUF938 domain-containing protein -
N0O74_RS22345 (N0O74_22345) 4796732..4798363 + 1632 WP_012478715.1 TldD/PmbA family protein -
N0O74_RS22350 (N0O74_22350) 4798394..4800028 + 1635 WP_005407530.1 TldD/PmbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-70)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49049.98 Da        Isoelectric Point: 6.9606

>T259389 WP_049419249.1 NZ_CP104863:4794079-4795401 [Stenotrophomonas maltophilia]
MGTLQVWMNGVEVALWDDVRNGSPRLSYVSQWISSPQSRPLSLSLPLLPDGESHRGNVVNDYFDNLLPDNVAIRNRIRDR
FATRGSDTFDLLEAIGRDCVGAVQLLPPAHPPEDIQQITCEVLDEAGVATILRQVTTGNLPGAPSRDDAFRISIAGAQEK
TGLLLHAGKWCIPTGNTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMHLLSAFDIPVAETQMGRFNDQRALIVERFDRR
LSADRRWWLRLPQEDMCQVFGLPAARKYESDGGPGIVPIMDLLRQSEHPEDRAIFFKTQILFWMLAATDGHAKNFSVHLE
AGGRFRLTPVYDVLSVYPILGRGPNQLDPRNAQLAMAVHGKNRHRKLHLVRRRHWNETARACGVADGAEPWIKTLIAAVE
PAIQQVTRQLPDDFPSNVSEPIFNGLRAAAARLSSMAPEA

Download         Length: 1323 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9584.97 Da        Isoelectric Point: 11.8468

>AT259389 WP_005407534.1 NZ_CP104863:4793818-4794075 [Stenotrophomonas maltophilia]
MDRPLHTVRTAQQLAPLMRAFRRQAGLSQAQLAERLGISRQAVGALERDPASASFERLMRIWAVLGLEVSLQQRSPQENT
SSLEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References