Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 4571933..4572581 Replicon chromosome
Accession NZ_CP104863
Organism Stenotrophomonas maltophilia strain CW002SM

Toxin (Protein)


Gene name PumA Uniprot ID B2FJ07
Locus tag N0O74_RS21385 Protein ID WP_012478870.1
Coordinates 4572294..4572581 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag N0O74_RS21380 Protein ID WP_012478871.1
Coordinates 4571933..4572235 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0O74_RS21350 (N0O74_21350) 4566948..4567169 - 222 WP_261728077.1 CsbD family protein -
N0O74_RS21355 (N0O74_21355) 4567377..4567514 - 138 WP_005407710.1 entericidin A/B family lipoprotein -
N0O74_RS21360 (N0O74_21360) 4567675..4568562 - 888 WP_261728512.1 arginase -
N0O74_RS21365 (N0O74_21365) 4568453..4570408 - 1956 WP_261728078.1 DUF3011 domain-containing protein -
N0O74_RS21370 (N0O74_21370) 4571065..4571472 + 408 WP_044569408.1 hypothetical protein -
N0O74_RS21375 (N0O74_21375) 4571552..4571875 + 324 WP_012478872.1 hypothetical protein -
N0O74_RS21380 (N0O74_21380) 4571933..4572235 - 303 WP_012478871.1 putative addiction module antidote protein Antitoxin
N0O74_RS21385 (N0O74_21385) 4572294..4572581 - 288 WP_012478870.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N0O74_RS21390 (N0O74_21390) 4572815..4573414 + 600 WP_012478869.1 hypothetical protein -
N0O74_RS21395 (N0O74_21395) 4573442..4574566 + 1125 WP_012478868.1 hypothetical protein -
N0O74_RS21400 (N0O74_21400) 4574906..4575454 - 549 WP_261728513.1 DUF3313 domain-containing protein -
N0O74_RS21405 (N0O74_21405) 4576015..4577121 - 1107 WP_261728079.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-95)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10802.42 Da        Isoelectric Point: 10.8940

>T259388 WP_012478870.1 NZ_CP104863:c4572581-4572294 [Stenotrophomonas maltophilia]
MKIQRTRQFATWIDALKDVTARARILARIGRLAEGHPGDHRYLGDGISELRIDAGPGYRLYYTQRGRQLLILLVGGDKSS
QQRDIEKAREIARAL

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10738.32 Da        Isoelectric Point: 8.0343

>AT259388 WP_012478871.1 NZ_CP104863:c4572235-4571933 [Stenotrophomonas maltophilia]
MATKKKVELKSFDVAEHLRTPEEMAAYLDACIEESDGDSAFIAKALGDIARAQGMSKVARAAGLSRESLYRALSGERSPD
FATILKVTRALGVRLHASAV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A854E218

Antitoxin

Source ID Structure

References