259386

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5074355..5074959 Replicon chromosome
Accession NZ_CP104861
Organism Pseudomonas fragi strain D12

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag N7D90_RS23265 Protein ID WP_261740171.1
Coordinates 5074762..5074959 (-) Length 66 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N7D90_RS23260 Protein ID WP_261740170.1
Coordinates 5074355..5074765 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7D90_RS23240 (N7D90_23240) 5069624..5070604 + 981 WP_261740166.1 integrase domain-containing protein -
N7D90_RS23245 (N7D90_23245) 5070601..5070888 + 288 WP_261740167.1 hypothetical protein -
N7D90_RS23250 (N7D90_23250) 5070914..5072503 - 1590 WP_261740168.1 TIGR04141 family sporadically distributed protein -
N7D90_RS23255 (N7D90_23255) 5072948..5073817 - 870 WP_261740169.1 AraC family transcriptional regulator -
N7D90_RS23260 (N7D90_23260) 5074355..5074765 - 411 WP_261740170.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N7D90_RS23265 (N7D90_23265) 5074762..5074959 - 198 WP_261740171.1 type II toxin-antitoxin system HicA family toxin Toxin
N7D90_RS23270 (N7D90_23270) 5075238..5075738 + 501 WP_261740172.1 sigma-70 family RNA polymerase sigma factor -
N7D90_RS23275 (N7D90_23275) 5075738..5076685 + 948 WP_261740173.1 FecR domain-containing protein -
N7D90_RS23280 (N7D90_23280) 5076798..5079236 + 2439 WP_261740174.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7145.34 Da        Isoelectric Point: 10.9003

>T259386 WP_261740171.1 NZ_CP104861:c5074959-5074762 [Pseudomonas fragi]
VRSRELIELLIADGWFEIAVKGSHHQFKHPAKAGRVTVPHPKAEIAKGTLHNILKSAGLKGELRS

Download         Length: 198 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14773.67 Da        Isoelectric Point: 4.4621

>AT259386 WP_261740170.1 NZ_CP104861:c5074765-5074355 [Pseudomonas fragi]
MKFPVVLHKDADSEFSVTVPDVPGCFSAGSTFSQALDNVLEALALHLEGVVADGGELPQAKDVDAHLDNPDYVGGIWAVV
DFDLTPYLGKSVRFNASLPENLLLRIDERVSKDHRYASRSGFLATAALRELSIQVF

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References