259383

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 3773541..3775258 Replicon chromosome
Accession NZ_CP104861
Organism Pseudomonas fragi strain D12

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag N7D90_RS17505 Protein ID WP_261739184.1
Coordinates 3773541..3774425 (+) Length 295 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag N7D90_RS17510 Protein ID WP_261739185.1
Coordinates 3774422..3775258 (+) Length 279 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7D90_RS17475 (N7D90_17475) 3768629..3769072 - 444 WP_261739179.1 GNAT family N-acetyltransferase -
N7D90_RS17480 (N7D90_17480) 3769538..3770374 + 837 WP_261742471.1 ABC transporter ATP-binding protein -
N7D90_RS17485 (N7D90_17485) 3770413..3771414 + 1002 WP_261739180.1 ABC transporter substrate-binding protein -
N7D90_RS17490 (N7D90_17490) 3771443..3772219 + 777 WP_261739181.1 ABC transporter permease -
N7D90_RS17495 (N7D90_17495) 3772219..3772983 + 765 WP_261739182.1 SDR family oxidoreductase -
N7D90_RS17500 (N7D90_17500) 3772997..3773536 + 540 WP_261739183.1 cupin domain-containing protein -
N7D90_RS17505 (N7D90_17505) 3773541..3774425 + 885 WP_261739184.1 alpha/beta hydrolase Toxin
N7D90_RS17510 (N7D90_17510) 3774422..3775258 + 837 WP_261739185.1 IclR family transcriptional regulator Antitoxin
N7D90_RS17515 (N7D90_17515) 3775260..3776057 + 798 WP_261739186.1 SDR family oxidoreductase -
N7D90_RS17520 (N7D90_17520) 3776050..3777732 + 1683 WP_261739187.1 thiamine pyrophosphate-binding protein -
N7D90_RS17525 (N7D90_17525) 3777743..3778546 + 804 WP_261739188.1 aspartate dehydrogenase -
N7D90_RS17530 (N7D90_17530) 3778581..3780077 + 1497 WP_261739189.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(47-278)

Antitoxin

Transcription regulator IclR, N-terminal

(19-68)


Sequences

Toxin        


Download         Length: 295 a.a.        Molecular weight: 31236.73 Da        Isoelectric Point: 7.1715

>T259383 WP_261739184.1 NZ_CP104861:3773541-3774425 [Pseudomonas fragi]
MLHATDHLTPTLTADLEARLAVNFPLRTLDVAGGRQSLRECGSGPAIVLLHGIGSGAASWLAVAQLLAQRVRVIAWDAPG
YGESSPLRSLAPDASDYAERLRQMLDALDIERCVLVGHSLGAITATAFASGAQQQRVSRLVLISPAQGYGHPSRKIQGQA
VRLKRLADLEYPGIQAMAEQRSAYMLSPGASPKDHAWVRWNMARLNPEGYRQAIELLCGDDLLRHPPLSMPCDVHCGAAD
GITTPDSCRVLAQTLGASFSLIDSAGHASPIEQPYAVAGQLAIAIKQSLTGASL

Download         Length: 885 bp

Antitoxin


Download         Length: 279 a.a.        Molecular weight: 30784.21 Da        Isoelectric Point: 6.0425

>AT259383 WP_261739185.1 NZ_CP104861:3774422-3775258 [Pseudomonas fragi]
MTDSELPKDAQDKYIVPGLERGLLLLCEFTRSNRTLTAPELARRLALPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDRVNYPSNLVVRDGRSIVYVAKVSPPSVFSSAVNVGTRLPAHATVLGRILLEDLSLS
ELRELFPEEHLEQHSPCTPKTALELFDMVQADRERGFVSGEGFFESSISTVAAPVRDESSRIVAALGVTIPTAQIAHVNF
NELLLQVRRSADELSRLLNYNSGAANDGHNRVTALMRD

Download         Length: 837 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References