Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 14921..15576 | Replicon | plasmid pTL-2 |
| Accession | NZ_CP104859 | ||
| Organism | Salmonella sp. 3C | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | M7RF18 |
| Locus tag | N7E69_RS23820 | Protein ID | WP_000812999.1 |
| Coordinates | 14921..15349 (-) | Length | 143 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | H9AC95 |
| Locus tag | N7E69_RS23825 | Protein ID | WP_001261283.1 |
| Coordinates | 15346..15576 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N7E69_RS23785 (N7E69_23785) | 10322..11086 | + | 765 | WP_000827659.1 | K88 minor fimbrial subunit faeI | - |
| N7E69_RS23790 (N7E69_23790) | 11073..11348 | + | 276 | WP_001020576.1 | hypothetical protein | - |
| N7E69_RS23795 (N7E69_23795) | 11348..12061 | + | 714 | WP_000801115.1 | hypothetical protein | - |
| N7E69_RS23800 (N7E69_23800) | 12186..12770 | + | 585 | WP_001575501.1 | hypothetical protein | - |
| N7E69_RS23805 (N7E69_23805) | 12879..13055 | + | 177 | WP_139782396.1 | FaeA/PapI family transcriptional regulator | - |
| N7E69_RS23810 (N7E69_23810) | 13316..13477 | + | 162 | WP_001816720.1 | hypothetical protein | - |
| N7E69_RS23815 (N7E69_23815) | 13503..14351 | + | 849 | WP_000175391.1 | SdiA-regulated domain-containing protein | - |
| N7E69_RS23820 (N7E69_23820) | 14921..15349 | - | 429 | WP_000812999.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| N7E69_RS23825 (N7E69_23825) | 15346..15576 | - | 231 | WP_001261283.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| N7E69_RS23830 (N7E69_23830) | 16321..16539 | + | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | - |
| N7E69_RS23835 (N7E69_23835) | 16541..16846 | + | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | - |
| N7E69_RS23840 (N7E69_23840) | 16848..17138 | + | 291 | WP_001266176.1 | hypothetical protein | - |
| N7E69_RS23845 (N7E69_23845) | 17135..17656 | + | 522 | WP_000198608.1 | hypothetical protein | - |
| N7E69_RS23850 (N7E69_23850) | 17691..18473 | + | 783 | WP_000082169.1 | site-specific integrase | - |
| N7E69_RS23855 (N7E69_23855) | 18482..19165 | + | 684 | WP_001751692.1 | EAL domain-containing protein | - |
| N7E69_RS23860 (N7E69_23860) | 19219..19707 | + | 489 | WP_001075507.1 | CaiF/GrlA family transcriptional regulator | - |
| N7E69_RS23865 (N7E69_23865) | 19701..20037 | + | 337 | Protein_30 | hypothetical protein | - |
| N7E69_RS23870 (N7E69_23870) | 19947..20369 | + | 423 | WP_225236769.1 | LysM peptidoglycan-binding domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaTEM-1A | faeH / faeI / spvC / spvB | 1..79524 | 79524 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 143 a.a. Molecular weight: 15483.03 Da Isoelectric Point: 7.6736
>T259380 WP_000812999.1 NZ_CP104859:c15349-14921 [Salmonella sp. 3C]
MKQPRTKTYMLDTCICSFIMREQSEAVLKRLEQAVLRGHRIVISAITYSEMRFGATGPKASPRLVQLVDAFCARLDAILP
WDRAAVDATTEIKVALCLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVS
MKQPRTKTYMLDTCICSFIMREQSEAVLKRLEQAVLRGHRIVISAITYSEMRFGATGPKASPRLVQLVDAFCARLDAILP
WDRAAVDATTEIKVALCLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVS
Download Length: 429 bp
>T259380 NZ_CP104859:c15349-14921 [Salmonella sp. 3C]
ATGAAACAGCCACGTACGAAGACCTATATGCTCGATACCTGTATCTGTTCGTTCATCATGCGCGAGCAGTCGGAAGCGGT
GCTGAAGCGCCTTGAGCAGGCGGTGCTGCGCGGCCACCGTATCGTGATCTCGGCCATCACCTACTCCGAGATGCGCTTCG
GCGCCACCGGACCTAAGGCCTCGCCGCGTCTCGTCCAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCC
TGGGATCGCGCTGCGGTAGACGCCACCACGGAGATTAAGGTGGCACTGTGCCTCGCCGGGACGCCGATCGGTCCGAACGA
CACGGCGATTGCCGGGCATGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGG
GCCTGGTACTGGAAGACTGGGTAAGTTAA
ATGAAACAGCCACGTACGAAGACCTATATGCTCGATACCTGTATCTGTTCGTTCATCATGCGCGAGCAGTCGGAAGCGGT
GCTGAAGCGCCTTGAGCAGGCGGTGCTGCGCGGCCACCGTATCGTGATCTCGGCCATCACCTACTCCGAGATGCGCTTCG
GCGCCACCGGACCTAAGGCCTCGCCGCGTCTCGTCCAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCC
TGGGATCGCGCTGCGGTAGACGCCACCACGGAGATTAAGGTGGCACTGTGCCTCGCCGGGACGCCGATCGGTCCGAACGA
CACGGCGATTGCCGGGCATGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGG
GCCTGGTACTGGAAGACTGGGTAAGTTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8737.83 Da Isoelectric Point: 4.3775
>AT259380 WP_001261283.1 NZ_CP104859:c15576-15346 [Salmonella sp. 3C]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVVSDEGRFEL
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVVSDEGRFEL
Download Length: 231 bp
>AT259380 NZ_CP104859:c15576-15346 [Salmonella sp. 3C]
ATGAGAACCGTATCCATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAAATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCTGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGCTTTGAGCTATGA
ATGAGAACCGTATCCATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAAATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCTGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGCTTTGAGCTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | M7RF18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6X6R7C5 |