Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1086707..1087241 Replicon chromosome
Accession NC_016809
Organism Haemophilus influenzae 10810

Toxin (Protein)


Gene name relE Uniprot ID Q849T7
Locus tag HIB_RS05575 Protein ID WP_015701940.1
Coordinates 1086707..1086997 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X4XNI1
Locus tag HIB_RS05580 Protein ID WP_015701941.1
Coordinates 1086987..1087241 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIB_RS05565 1084108..1084611 + 504 WP_015701938.1 hypothetical protein -
HIB_RS05570 1084611..1085645 + 1035 WP_015701939.1 DNA polymerase III subunit delta -
HIB_RS10330 1086113..1086250 - 138 WP_005663612.1 hypothetical protein -
HIB_RS05575 1086707..1086997 - 291 WP_015701940.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HIB_RS05580 1086987..1087241 - 255 WP_015701941.1 stability protein StbD Antitoxin
HIB_RS05585 1087332..1087538 - 207 WP_041175054.1 hypothetical protein -
HIB_RS05590 1087547..1087771 - 225 WP_015701942.1 hypothetical protein -
HIB_RS05595 1087771..1088079 - 309 Protein_1059 P2 family phage major capsid protein -
HIB_RS05605 1088598..1090664 - 2067 WP_015701944.1 glycine--tRNA ligase subunit beta -
HIB_RS05610 1091001..1091366 - 366 WP_015701945.1 endonuclease domain-containing protein -
HIB_RS05615 1091396..1091656 - 261 WP_005651528.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11496.44 Da        Isoelectric Point: 10.6484

>T25938 WP_015701940.1 NC_016809:c1086997-1086707 [Haemophilus influenzae 10810]
MTYKLIFDKRALKEWNKLGETLRQQFKNKLAERMINPRIQADKLKGENDLYKIKLRSAGYRLVYQVRDQEITIIVVSIGK
RERLEVYKTAEQRTAH

Download         Length: 291 bp

>T25938 NC_016809:c1086997-1086707 [Haemophilus influenzae 10810]
ATGACTTATAAACTCATTTTTGATAAACGTGCATTAAAAGAATGGAATAAGTTAGGAGAAACTTTACGCCAGCAATTTAA
AAATAAATTAGCCGAAAGAATGATAAATCCACGCATTCAAGCCGATAAATTAAAGGGCGAAAATGATTTATATAAAATAA
AATTAAGAAGCGCAGGCTATCGATTAGTTTATCAAGTAAGAGATCAGGAAATCACCATTATTGTTGTATCTATTGGAAAA
AGGGAACGATTAGAAGTCTATAAAACCGCAGAACAAAGAACAGCCCACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9449.81 Da        Isoelectric Point: 4.0737

>AT25938 WP_015701941.1 NC_016809:c1087241-1086987 [Haemophilus influenzae 10810]
MALHQILAEQAASITDLKRNPMGVIQESESGIVAILNRNQPAFYCITPELFSHMQELIEDLELSRMANERLATLEPVEVD
LNDL

Download         Length: 255 bp

>AT25938 NC_016809:c1087241-1086987 [Haemophilus influenzae 10810]
ATGGCATTACATCAAATACTGGCAGAACAAGCGGCAAGCATTACAGACTTAAAACGAAACCCAATGGGCGTAATTCAAGA
AAGCGAAAGCGGAATAGTCGCAATATTGAACCGAAACCAACCCGCATTTTATTGCATCACCCCAGAATTATTCTCTCATA
TGCAAGAATTAATCGAAGATTTAGAACTCAGCAGAATGGCAAATGAACGGCTTGCCACTCTTGAACCTGTAGAGGTTGAT
CTAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q849T7

Antitoxin

Source ID Structure
AlphaFold DB A0A2X4XNI1

References