Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3040606..3041226 Replicon chromosome
Accession NZ_CP104858
Organism Salmonella sp. 3C

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag N7E69_RS14345 Protein ID WP_001280991.1
Coordinates 3040606..3040824 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag N7E69_RS14350 Protein ID WP_000344807.1
Coordinates 3040852..3041226 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7E69_RS14305 (3035829) 3035829..3036398 + 570 WP_000779802.1 YbaY family lipoprotein -
N7E69_RS14310 (3036431) 3036431..3036820 - 390 WP_000961287.1 MGMT family protein -
N7E69_RS14320 (3037051) 3037051..3038601 - 1551 WP_000213140.1 EAL domain-containing protein -
N7E69_RS14325 (3038826) 3038826..3039086 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
N7E69_RS14330 (3039092) 3039092..3039232 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
N7E69_RS14335 (3039288) 3039288..3039758 - 471 WP_000136183.1 YlaC family protein -
N7E69_RS14340 (3039876) 3039876..3040427 - 552 WP_001278787.1 maltose O-acetyltransferase -
N7E69_RS14345 (3040606) 3040606..3040824 - 219 WP_001280991.1 HHA domain-containing protein Toxin
N7E69_RS14350 (3040852) 3040852..3041226 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
N7E69_RS14355 (3041722) 3041722..3044871 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
N7E69_RS14360 (3044894) 3044894..3046087 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T259375 WP_001280991.1 NZ_CP104858:c3040824-3040606 [Salmonella sp. 3C]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT259375 WP_000344807.1 NZ_CP104858:c3041226-3040852 [Salmonella sp. 3C]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References