Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 2441424..2442000 Replicon chromosome
Accession NZ_CP104858
Organism Salmonella sp. 3C

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag N7E69_RS11585 Protein ID WP_001131963.1
Coordinates 2441424..2441711 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A5U1K3M6
Locus tag N7E69_RS11590 Protein ID WP_000063141.1
Coordinates 2441698..2442000 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7E69_RS11565 (2436554) 2436554..2436688 + 135 WP_001055725.1 hypothetical protein -
N7E69_RS11570 (2436910) 2436910..2437548 - 639 WP_227468645.1 N-6 DNA methylase -
N7E69_RS11575 (2437978) 2437978..2438553 - 576 WP_000593782.1 restriction endonuclease subunit S -
N7E69_RS11580 (2439166) 2439166..2441007 - 1842 WP_000974635.1 nuclease-related domain-containing DEAD/DEAH box helicase -
N7E69_RS11585 (2441424) 2441424..2441711 + 288 WP_001131963.1 BrnT family toxin Toxin
N7E69_RS11590 (2441698) 2441698..2442000 + 303 WP_000063141.1 BrnA antitoxin family protein Antitoxin
N7E69_RS11595 (2442075) 2442075..2443031 - 957 WP_000187843.1 GTPase -
N7E69_RS11600 (2443042) 2443042..2443245 - 204 WP_000460616.1 YbdD/YjiX family protein -
N7E69_RS11605 (2443340) 2443340..2445490 - 2151 WP_000379928.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2433162..2442000 8838


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T259372 WP_001131963.1 NZ_CP104858:2441424-2441711 [Salmonella sp. 3C]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11431.99 Da        Isoelectric Point: 9.8948

>AT259372 WP_000063141.1 NZ_CP104858:2441698-2442000 [Salmonella sp. 3C]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRDKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A5U1K3M6

References