Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2350082..2350598 Replicon chromosome
Accession NZ_CP104858
Organism Salmonella sp. 3C

Toxin (Protein)


Gene name relE Uniprot ID M7RIY5
Locus tag N7E69_RS11135 Protein ID WP_000220574.1
Coordinates 2350314..2350598 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag N7E69_RS11130 Protein ID WP_000212724.1
Coordinates 2350082..2350324 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7E69_RS11110 (2345102) 2345102..2346235 + 1134 WP_000459958.1 amidohydrolase/deacetylase family metallohydrolase -
N7E69_RS11115 (2346219) 2346219..2347337 + 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
N7E69_RS11120 (2347334) 2347334..2348074 + 741 WP_261743246.1 KDGP aldolase family protein -
N7E69_RS11125 (2348091) 2348091..2350004 + 1914 WP_001212138.1 PRD domain-containing protein -
N7E69_RS11130 (2350082) 2350082..2350324 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N7E69_RS11135 (2350314) 2350314..2350598 + 285 WP_000220574.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N7E69_RS11140 (2350602) 2350602..2351066 - 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N7E69_RS11145 (2351283) 2351283..2353421 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
N7E69_RS11150 (2353830) 2353830..2355482 - 1653 WP_000155053.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10869.68 Da        Isoelectric Point: 9.8739

>T259370 WP_000220574.1 NZ_CP104858:2350314-2350598 [Salmonella sp. 3C]
MTYELEFDPRALKEWHKLGDTVKAQIKKKLADVLLDPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT259370 WP_000212724.1 NZ_CP104858:2350082-2350324 [Salmonella sp. 3C]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M7RIY5

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References