Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 863321..863925 Replicon chromosome
Accession NC_016809
Organism Haemophilus influenzae 10810

Toxin (Protein)


Gene name relE Uniprot ID A0A822VCP0
Locus tag HIB_RS04480 Protein ID WP_015701819.1
Coordinates 863617..863925 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q4QMK8
Locus tag HIB_RS04475 Protein ID WP_005692346.1
Coordinates 863321..863617 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIB_RS04460 859087..860472 + 1386 WP_015701816.1 L-seryl-tRNA(Sec) selenium transferase -
HIB_RS04465 860469..862328 + 1860 WP_015701817.1 selenocysteine-specific translation elongation factor -
HIB_RS04470 862347..863201 + 855 WP_015701818.1 DUF3298 domain-containing protein -
HIB_RS04475 863321..863617 + 297 WP_005692346.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HIB_RS04480 863617..863925 + 309 WP_015701819.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HIB_RS04485 863982..867185 - 3204 WP_015701820.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
HIB_RS04490 867517..868815 + 1299 WP_015701821.1 trigger factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(8-98)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11919.74 Da        Isoelectric Point: 8.9408

>T25937 WP_015701819.1 NC_016809:863617-863925 [Haemophilus influenzae 10810]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCHIQGNLVLIYQYV
IQDKFDELKFSRLNTHSQTALK

Download         Length: 309 bp

>T25937 NC_016809:863617-863925 [Haemophilus influenzae 10810]
ATGTCAGAAGAGAAGCCATTAAAAGTAAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGCAATTTGGTACTGATTTACCAATACGTT
ATACAGGATAAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11003.27 Da        Isoelectric Point: 4.2845

>AT25937 WP_005692346.1 NC_016809:863321-863617 [Haemophilus influenzae 10810]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp

>AT25937 NC_016809:863321-863617 [Haemophilus influenzae 10810]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGCAAACAAAATCAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTATTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTTTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822VCP0

Antitoxin

Source ID Structure
AlphaFold DB Q4QMK8

References