Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2242890..2243671 Replicon chromosome
Accession NZ_CP104858
Organism Salmonella sp. 3C

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag N7E69_RS10560 Protein ID WP_000625912.1
Coordinates 2243180..2243671 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag N7E69_RS10555 Protein ID WP_001110450.1
Coordinates 2242890..2243183 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7E69_RS10525 (2239214) 2239214..2240119 + 906 WP_001268195.1 YjiK family protein -
N7E69_RS10530 (2240413) 2240413..2240682 - 270 WP_077906657.1 hypothetical protein -
N7E69_RS10535 (2240690) 2240690..2240905 - 216 WP_001595136.1 hypothetical protein -
N7E69_RS10540 (2240928) 2240928..2241215 - 288 WP_001269916.1 transcriptional regulator RtsB -
N7E69_RS10545 (2241212) 2241212..2242087 - 876 WP_108610913.1 AraC family transcriptional regulator -
N7E69_RS10550 (2242351) 2242351..2242573 - 223 Protein_2044 hypothetical protein -
N7E69_RS10555 (2242890) 2242890..2243183 + 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
N7E69_RS10560 (2243180) 2243180..2243671 + 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
N7E69_RS10565 (2243919) 2243919..2244671 - 753 WP_000842432.1 non-specific acid phosphatase -
N7E69_RS10570 (2244771) 2244771..2244848 - 78 Protein_2048 porin family protein -
N7E69_RS10575 (2245228) 2245228..2245302 + 75 Protein_2049 helix-turn-helix domain-containing protein -
N7E69_RS10585 (2245573) 2245573..2246148 - 576 WP_001188509.1 transcriptional regulator -
N7E69_RS10590 (2246185) 2246185..2247888 - 1704 WP_000068885.1 protein-disulfide reductase DsbD -
N7E69_RS10595 (2247864) 2247864..2248211 - 348 WP_000887832.1 divalent cation tolerance protein CutA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T259369 WP_000625912.1 NZ_CP104858:2243180-2243671 [Salmonella sp. 3C]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT259369 WP_001110450.1 NZ_CP104858:2242890-2243183 [Salmonella sp. 3C]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References