Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1542823..1543583 Replicon chromosome
Accession NZ_CP104858
Organism Salmonella sp. 3C

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag N7E69_RS07350 Protein ID WP_000533909.1
Coordinates 1542823..1543308 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag N7E69_RS07355 Protein ID WP_000965886.1
Coordinates 1543296..1543583 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7E69_RS07320 (1537891) 1537891..1538553 + 663 WP_000747548.1 OmpA family lipoprotein -
N7E69_RS07325 (1538772) 1538772..1539750 + 979 Protein_1428 glyoxylate/hydroxypyruvate reductase GhrB -
N7E69_RS07330 (1539800) 1539800..1540510 - 711 WP_000190524.1 DUF3053 domain-containing protein -
N7E69_RS07335 (1540949) 1540949..1541239 + 291 WP_000455790.1 HTH-type transcriptional regulator -
N7E69_RS07340 (1541527) 1541527..1541739 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
N7E69_RS07345 (1541913) 1541913..1542452 + 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
N7E69_RS07350 (1542823) 1542823..1543308 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
N7E69_RS07355 (1543296) 1543296..1543583 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
N7E69_RS07360 (1543761) 1543761..1544228 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
N7E69_RS07365 (1544445) 1544445..1544798 - 354 Protein_1436 IS3 family transposase -
N7E69_RS07370 (1545188) 1545188..1547257 - 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
N7E69_RS07375 (1547267) 1547267..1548178 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T259366 WP_000533909.1 NZ_CP104858:c1543308-1542823 [Salmonella sp. 3C]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT259366 WP_000965886.1 NZ_CP104858:c1543583-1543296 [Salmonella sp. 3C]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References