Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 755398..756212 Replicon chromosome
Accession NZ_CP104858
Organism Salmonella sp. 3C

Toxin (Protein)


Gene name TacT3 Uniprot ID M7RPS8
Locus tag N7E69_RS03560 Protein ID WP_000971649.1
Coordinates 755685..756212 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag N7E69_RS03555 Protein ID WP_000855694.1
Coordinates 755398..755688 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7E69_RS03535 (751312) 751312..753000 - 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -
N7E69_RS03540 (752997) 752997..753647 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
N7E69_RS03545 (754103) 754103..754546 + 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
N7E69_RS03550 (754950) 754950..755128 + 179 Protein_691 IS3 family transposase -
N7E69_RS03555 (755398) 755398..755688 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
N7E69_RS03560 (755685) 755685..756212 + 528 WP_000971649.1 GNAT family N-acetyltransferase Toxin
N7E69_RS03565 (756285) 756285..756694 - 410 Protein_694 IS5/IS1182 family transposase -
N7E69_RS03570 (756927) 756927..757583 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
N7E69_RS03575 (757755) 757755..758249 - 495 WP_000424948.1 hypothetical protein -
N7E69_RS03580 (758276) 758276..758944 - 669 WP_000445914.1 hypothetical protein -
N7E69_RS03585 (759101) 759101..759340 - 240 Protein_698 hypothetical protein -
N7E69_RS03590 (759531) 759531..759929 - 399 Protein_699 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 756285..756425 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19026.88 Da        Isoelectric Point: 9.3905

>T259361 WP_000971649.1 NZ_CP104858:755685-756212 [Salmonella sp. 3C]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT259361 WP_000855694.1 NZ_CP104858:755398-755688 [Salmonella sp. 3C]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VVF5

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References