259359

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 10244..10815 Replicon plasmid pNY13412
Accession NZ_CP104857
Organism Enterococcus faecalis strain NY13412

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag N7M47_RS14845 Protein ID WP_128701244.1
Coordinates 10474..10815 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3KHK9
Locus tag N7M47_RS14840 Protein ID WP_002362431.1
Coordinates 10244..10474 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7M47_RS14805 (N7M47_14810) 5355..5606 - 252 WP_064686964.1 hypothetical protein -
N7M47_RS14810 (N7M47_14815) 5699..5827 + 129 WP_258076850.1 hypothetical protein -
N7M47_RS14815 (N7M47_14820) 6217..8013 - 1797 WP_064686966.1 AIPR family protein -
N7M47_RS14820 (N7M47_14825) 8217..8417 - 201 WP_064686967.1 hypothetical protein -
N7M47_RS14825 (N7M47_14830) 8901..9122 - 222 WP_080474121.1 hypothetical protein -
N7M47_RS14830 (N7M47_14835) 9119..9403 - 285 WP_064686968.1 hypothetical protein -
N7M47_RS14835 (N7M47_14840) 9420..10040 - 621 WP_161970397.1 recombinase family protein -
N7M47_RS14840 (N7M47_14845) 10244..10474 + 231 WP_002362431.1 hypothetical protein Antitoxin
N7M47_RS14845 (N7M47_14850) 10474..10815 + 342 WP_128701244.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
N7M47_RS14850 (N7M47_14855) 10929..11867 + 939 WP_128701245.1 hypothetical protein -
N7M47_RS14855 (N7M47_14860) 12133..12735 + 603 WP_128701246.1 Fic family protein -
N7M47_RS14860 (N7M47_14865) 12820..13680 + 861 WP_128701247.1 abortive infection system antitoxin AbiGi family protein -
N7M47_RS14865 (N7M47_14870) 13682..14893 + 1212 WP_128701248.1 abortive infection system toxin AbiGii family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid dfrG / erm(B) / aph(3')-III / ant(6)-Ia / aac(6')-aph(2'') - 1..49839 49839


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13201.42 Da        Isoelectric Point: 9.3988

>T259359 WP_128701244.1 NZ_CP104857:10474-10815 [Enterococcus faecalis]
MSDEKKYIPKKGDIVWIDFDPSAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDEMETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKINQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8510.42 Da        Isoelectric Point: 4.3855

>AT259359 WP_002362431.1 NZ_CP104857:10244-10474 [Enterococcus faecalis]
MLTTKSRKQGSSVVLTLPSNNGQKPKADQEYIVMYSDDGTITLVPKLQDPFSGGSEGEYYEKDEWHDIEPGGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB R3KHK9

References