Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2943452..2944023 Replicon chromosome
Accession NZ_CP104856
Organism Enterococcus faecalis strain NY13412

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag N7M47_RS14300 Protein ID WP_002354774.1
Coordinates 2943452..2943793 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag N7M47_RS14305 Protein ID WP_002354773.1
Coordinates 2943793..2944023 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7M47_RS14295 (2939467) 2939467..2943081 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
N7M47_RS14300 (2943452) 2943452..2943793 - 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
N7M47_RS14305 (2943793) 2943793..2944023 - 231 WP_002354773.1 hypothetical protein Antitoxin
N7M47_RS14310 (2944197) 2944197..2944412 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
N7M47_RS14315 (2944551) 2944551..2945543 + 993 WP_002378862.1 biotin--[acetyl-CoA-carboxylase] ligase -
N7M47_RS14320 (2945710) 2945710..2946348 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
N7M47_RS14325 (2947033) 2947033..2948649 + 1617 WP_002378864.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T259354 WP_002354774.1 NZ_CP104856:c2943793-2943452 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT259354 WP_002354773.1 NZ_CP104856:c2944023-2943793 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References