259350

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 1923072..1923765 Replicon chromosome
Accession NZ_CP104856
Organism Enterococcus faecalis strain NY13412

Toxin (Protein)


Gene name IrrE Uniprot ID S4BLV4
Locus tag N7M47_RS09645 Protein ID WP_002378467.1
Coordinates 1923421..1923765 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag N7M47_RS09640 Protein ID WP_002364355.1
Coordinates 1923072..1923404 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7M47_RS09595 (1918544) 1918544..1919278 - 735 WP_002378463.1 ERF family protein -
N7M47_RS09600 (1919271) 1919271..1919588 - 318 WP_002357007.1 hypothetical protein -
N7M47_RS09605 (1919808) 1919808..1920362 + 555 WP_002357006.1 hypothetical protein -
N7M47_RS09610 (1920789) 1920789..1920983 - 195 WP_002378464.1 hypothetical protein -
N7M47_RS09615 (1921020) 1921020..1921229 - 210 WP_002378465.1 hypothetical protein -
N7M47_RS09620 (1921284) 1921284..1921472 + 189 WP_002357001.1 YegP family protein -
N7M47_RS09625 (1921498) 1921498..1922223 - 726 WP_002378466.1 phage regulatory protein -
N7M47_RS09630 (1922262) 1922262..1922573 - 312 WP_002381719.1 hypothetical protein -
N7M47_RS09635 (1922584) 1922584..1922760 - 177 WP_002364354.1 helix-turn-helix transcriptional regulator -
N7M47_RS09640 (1923072) 1923072..1923404 + 333 WP_002364355.1 helix-turn-helix transcriptional regulator Antitoxin
N7M47_RS09645 (1923421) 1923421..1923765 + 345 WP_002378467.1 ImmA/IrrE family metallo-endopeptidase Toxin
N7M47_RS09650 (1923801) 1923801..1924529 + 729 WP_002378468.1 potassium channel family protein -
N7M47_RS09655 (1924629) 1924629..1925777 + 1149 WP_002378469.1 site-specific integrase -
N7M47_RS09660 (1925814) 1925814..1926248 - 435 Protein_1870 competence type IV pilus minor pilin ComGD -
N7M47_RS09665 (1926245) 1926245..1926520 - 276 WP_002356991.1 competence type IV pilus major pilin ComGC -
N7M47_RS09670 (1926520) 1926520..1927566 - 1047 WP_002369171.1 competence type IV pilus assembly protein ComGB -
N7M47_RS09675 (1927523) 1927523..1928491 - 969 WP_002364362.1 competence type IV pilus ATPase ComGA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1886734..1926221 39487


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(22-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-63)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13712.62 Da        Isoelectric Point: 5.5523

>T259350 WP_002378467.1 NZ_CP104856:1923421-1923765 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYIELYKIPSFRNKMEAEADY
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLN

Download         Length: 345 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12691.16 Da        Isoelectric Point: 4.6307

>AT259350 WP_002364355.1 NZ_CP104856:1923072-1923404 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BLV4

Antitoxin

Source ID Structure

References