Detailed information of TA system TA025935

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 805065..805713
• Replicon: chromosome
• Accession: NC_016809
• Organism: Haemophilus influenzae 10810

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: -
• Locus tag: HIB_RS04215
• Protein ID: WP_015701793.1
• Coordinates: 805354..805713 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: HIB_RS04210
• Protein ID: WP_005650837.1
• Coordinates: 805065..805361 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HIB_RS04185	800476..801033	-	558	WP_015701788.1	DNA-3-methyladenine glycosylase I	-
HIB_RS04190	801030..801848	-	819	WP_015701789.1	shikimate dehydrogenase	-
HIB_RS04195	801852..802403	-	552	WP_015701790.1	Sua5/YciO/YrdC/YwlC family protein	-
HIB_RS04200	802419..802955	-	537	WP_015701791.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
HIB_RS04205	802965..804881	-	1917	WP_015701792.1	ABC transporter ATP-binding protein	-
HIB_RS04210	805065..805361	-	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
HIB_RS04215	805354..805713	-	360	WP_015701793.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HIB_RS04220	805983..808952	-	2970	WP_015701794.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (36-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 14293.66 Da
• Isoelectric Point: 10.1179

>T25935 WP_015701793.1 NC_016809:c805713-805354 [Haemophilus influenzae 10810]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVKLLSELGTSVGKPYVKHLDGEIWELRPIRDRILFAKLM
DGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Nucleotide

• Length: 360 bp

>T25935 NC_016809:c805713-805354 [Haemophilus influenzae 10810]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAGTATCTGCTATCGCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAAAGTTATTAAGCGAACTCGGGACATCTGTTGGCA
AACCCTATGTGAAACATTTAGACGGTGAAATTTGGGAACTTCGCCCAATTCGGGATCGCATCTTGTTTGCAAAATTAATG
GACGGTCGCTTTGTCTTACTACATCAATTTATGAAGAAAACACAAAAAACGCCAAAACGAGAAATCCAAACTGCCCAACA
ACGCTTAAGTGAATTAAAAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT25935 WP_005650837.1 NC_016809:c805361-805065 [Haemophilus influenzae 10810]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT25935 NC_016809:c805361-805065 [Haemophilus influenzae 10810]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAGCTTGAAACGTTGTTAAAATTG
CTCGCTCCCTTGGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA