Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 582735..583212 Replicon chromosome
Accession NC_016809
Organism Haemophilus influenzae 10810

Toxin (Protein)


Gene name VapD Uniprot ID -
Locus tag HIB_RS10350 Protein ID WP_015701676.1
Coordinates 582735..582872 (-) Length 46 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag HIB_RS03050 Protein ID WP_005649350.1
Coordinates 583021..583212 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIB_RS03025 577926..579596 - 1671 WP_015701673.1 fructose-specific PTS transporter subunit EIIC -
HIB_RS03030 579568..580539 - 972 WP_015701674.1 1-phosphofructokinase -
HIB_RS03035 580541..582040 - 1500 WP_015701675.1 fused PTS fructose transporter subunit IIA/HPr protein -
HIB_RS03040 582112..582642 - 531 WP_005686915.1 hypothetical protein -
HIB_RS10350 582735..582872 - 138 WP_015701676.1 virulence-associated protein VapD Toxin
HIB_RS03050 583021..583212 - 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
HIB_RS03055 583284..584582 - 1299 WP_015701677.1 hemolysin family protein -
HIB_RS03060 584633..585157 - 525 WP_015701678.1 DUF1523 family protein -
HIB_RS03065 585184..585966 - 783 WP_005649353.1 YchF/TatD family DNA exonuclease -
HIB_RS03070 586021..587004 - 984 WP_015701679.1 DNA polymerase III subunit delta' -
HIB_RS03075 587001..587633 - 633 WP_041175109.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5422.16 Da        Isoelectric Point: 4.7105

>T25934 WP_015701676.1 NC_016809:c582872-582735 [Haemophilus influenzae 10810]
MNEDMANLFQAMNALKQLAWISQSVRDIRAFRIEQWSDFTDFIRN

Download         Length: 138 bp

>T25934 NC_016809:c582872-582735 [Haemophilus influenzae 10810]
ATGAATGAAGATATGGCGAATCTCTTTCAGGCAATGAATGCACTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGA
TATTCGCGCTTTTCGTATTGAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT25934 WP_005649350.1 NC_016809:c583212-583021 [Haemophilus influenzae 10810]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT25934 NC_016809:c583212-583021 [Haemophilus influenzae 10810]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGACATTTATCGATTAT
CTCACCTGCTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References