Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4336688..4337185 Replicon chromosome
Accession NZ_CP104851
Organism Escherichia coli strain GYX208DH4E-2

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag N6H16_RS21035 Protein ID WP_001173343.1
Coordinates 4336688..4336861 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID J7RC38
Locus tag N6H16_RS21040 Protein ID WP_001425728.1
Coordinates 4336889..4337185 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6H16_RS21025 (4333358) 4333358..4334815 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
N6H16_RS21030 (4335052) 4335052..4336569 + 1518 WP_001295074.1 lysine--tRNA ligase -
N6H16_RS21035 (4336688) 4336688..4336861 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
N6H16_RS21040 (4336889) 4336889..4337185 - 297 WP_001425728.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
N6H16_RS21045 (4337412) 4337412..4337684 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
N6H16_RS21050 (4337696) 4337696..4337926 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
N6H16_RS21055 (4338107) 4338107..4339738 + 1632 WP_001216487.1 sensor histidine kinase -
N6H16_RS21060 (4339735) 4339735..4340454 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T259337 WP_001173343.1 NZ_CP104851:c4336861-4336688 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11466.99 Da        Isoelectric Point: 4.2544

>AT259337 WP_001425728.1 NZ_CP104851:c4337185-4336889 [Escherichia coli]
MEGKNKFNTYVVSFNYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB J7RC38

References