Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1344557..1345182 Replicon chromosome
Accession NZ_CP104851
Organism Escherichia coli strain GYX208DH4E-2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N6H16_RS06565 Protein ID WP_000911330.1
Coordinates 1344784..1345182 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag N6H16_RS06560 Protein ID WP_000450524.1
Coordinates 1344557..1344784 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6H16_RS06535 (1340360) 1340360..1340830 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
N6H16_RS06540 (1340830) 1340830..1341402 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
N6H16_RS06545 (1341548) 1341548..1342426 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
N6H16_RS06550 (1342443) 1342443..1343477 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
N6H16_RS06555 (1343690) 1343690..1344403 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
N6H16_RS06560 (1344557) 1344557..1344784 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
N6H16_RS06565 (1344784) 1344784..1345182 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
N6H16_RS06570 (1345329) 1345329..1346192 + 864 WP_001267507.1 neutral zinc metallopeptidase -
N6H16_RS06575 (1346207) 1346207..1348222 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
N6H16_RS06580 (1348296) 1348296..1348637 + 342 Protein_1285 esterase -
N6H16_RS06585 (1348719) 1348719..1349465 - 747 WP_053906593.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T259326 WP_000911330.1 NZ_CP104851:1344784-1345182 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT259326 WP_000450524.1 NZ_CP104851:1344557-1344784 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References