Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4434991..4435586 Replicon chromosome
Accession NZ_CP104848
Organism Escherichia coli strain DFK.1

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag N7218_RS21895 Protein ID WP_000239579.1
Coordinates 4434991..4435341 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag N7218_RS21900 Protein ID WP_001223208.1
Coordinates 4435335..4435586 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7218_RS21875 (4430437) 4430437..4431459 - 1023 WP_001296689.1 ABC transporter permease -
N7218_RS21880 (4431473) 4431473..4432975 - 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
N7218_RS21885 (4433115) 4433115..4434071 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
N7218_RS21890 (4434381) 4434381..4434911 + 531 WP_000055075.1 inorganic diphosphatase -
N7218_RS21895 (4434991) 4434991..4435341 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
N7218_RS21900 (4435335) 4435335..4435586 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
N7218_RS21905 (4435798) 4435798..4436139 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
N7218_RS21910 (4436142) 4436142..4439921 - 3780 WP_000060945.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T259310 WP_000239579.1 NZ_CP104848:c4435341-4434991 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT259310 WP_001223208.1 NZ_CP104848:c4435586-4435335 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References