Detailed information of TA system TA025931

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 3792140..3792825
• Replicon: chromosome
• Accession: NC_016804
• Organism: Mycobacterium bovis BCG str. Mexico

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TIR9
• Locus tag: BCGMEX_RS17745
• Protein ID: WP_003417998.1
• Coordinates: 3792415..3792825 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BCGMEX_RS17740
• Protein ID: WP_003912220.1
• Coordinates: 3792140..3792418 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCGMEX_RS17720	3788129..3789730	-	1602	WP_003417969.1	FAD/NAD(P)-binding protein	-
BCGMEX_RS17725	3789747..3790451	-	705	WP_003417980.1	dTDP-4-amino-4,6-dideoxyglucose formyltransferase	-
BCGMEX_RS17730	3790569..3791135	-	567	WP_003417984.1	TetR/AcrR family transcriptional regulator	-
BCGMEX_RS17735	3791197..3792084	+	888	WP_003900050.1	alpha-ketoglutarate-dependent sulfate ester dioxygenase	-
BCGMEX_RS17740	3792140..3792418	+	279	WP_003912220.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
BCGMEX_RS17745	3792415..3792825	+	411	WP_003417998.1	type II toxin-antitoxin system VapC family toxin	Toxin
BCGMEX_RS17750	3792858..3794594	-	1737	WP_003418002.1	cholesterol oxidase	-
BCGMEX_RS17755	3794650..3795777	-	1128	WP_003418005.1	GuaB3 family IMP dehydrogenase-related protein	-
BCGMEX_RS17760	3795797..3797386	-	1590	WP_003900682.1	IMP dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-54)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14695.84 Da
• Isoelectric Point: 5.1784

>T25931 WP_003417998.1 NC_016804:3792415-3792825 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Nucleotide

• Length: 411 bp

>T25931 NC_016804:3792415-3792825 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10280.75 Da
• Isoelectric Point: 10.1819

>AT25931 WP_003912220.1 NC_016804:3792140-3792418 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Nucleotide

• Length: 279 bp

>AT25931 NC_016804:3792140-3792418 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCCGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Structures

Toxin

• AlphaFold DB: G0TIR9