Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4240110..4240764 Replicon chromosome
Accession NZ_CP104848
Organism Escherichia coli strain DFK.1

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag N7218_RS20895 Protein ID WP_000244765.1
Coordinates 4240110..4240517 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag N7218_RS20900 Protein ID WP_000354050.1
Coordinates 4240498..4240764 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7218_RS20875 (4236067) 4236067..4237800 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
N7218_RS20880 (4237806) 4237806..4238516 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N7218_RS20885 (4238541) 4238541..4239437 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
N7218_RS20890 (4239549) 4239549..4240070 + 522 WP_001055874.1 flavodoxin FldB -
N7218_RS20895 (4240110) 4240110..4240517 - 408 WP_000244765.1 protein YgfX Toxin
N7218_RS20900 (4240498) 4240498..4240764 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
N7218_RS20905 (4241007) 4241007..4241987 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
N7218_RS20910 (4242064) 4242064..4242723 - 660 WP_000250275.1 hemolysin III family protein -
N7218_RS20915 (4242887) 4242887..4243198 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
N7218_RS20920 (4243243) 4243243..4244676 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T259309 WP_000244765.1 NZ_CP104848:c4240517-4240110 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT259309 WP_000354050.1 NZ_CP104848:c4240764-4240498 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References