Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 871735..872570 Replicon chromosome
Accession NZ_CP104848
Organism Escherichia coli strain DFK.1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J2AEA6
Locus tag N7218_RS04290 Protein ID WP_000854759.1
Coordinates 872193..872570 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag N7218_RS04285 Protein ID WP_001295723.1
Coordinates 871735..872103 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7218_RS04260 (868851) 868851..869046 + 196 Protein_838 DUF905 family protein -
N7218_RS04265 (869164) 869164..869982 + 819 WP_001234738.1 DUF932 domain-containing protein -
N7218_RS04270 (870323) 870323..870796 + 474 WP_001542276.1 antirestriction protein -
N7218_RS04275 (870812) 870812..871288 + 477 WP_059333688.1 RadC family protein -
N7218_RS04280 (871351) 871351..871572 + 222 WP_000692345.1 DUF987 domain-containing protein -
N7218_RS04285 (871735) 871735..872103 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
N7218_RS04290 (872193) 872193..872570 + 378 WP_000854759.1 TA system toxin CbtA family protein Toxin
N7218_RS04295 (872567) 872567..873055 + 489 WP_000761690.1 DUF5983 family protein -
N7218_RS04300 (873072) 873072..873248 + 177 WP_000839286.1 DUF957 domain-containing protein -
N7218_RS04305 (873354) 873354..873503 + 150 Protein_847 hypothetical protein -
N7218_RS04310 (873870) 873870..874046 + 177 Protein_848 helix-turn-helix domain-containing protein -
N7218_RS04315 (874837) 874837..876459 + 1623 WP_001295726.1 Alw26I/Eco31I/Esp3I family type II restriction adenine-specific DNA-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 865934..888033 22099


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14144.26 Da        Isoelectric Point: 7.3249

>T259291 WP_000854759.1 NZ_CP104848:872193-872570 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT259291 WP_001295723.1 NZ_CP104848:871735-872103 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2AEA6

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References