Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3675578..3676252 Replicon chromosome
Accession NC_016804
Organism Mycobacterium bovis BCG str. Mexico

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag BCGMEX_RS17300 Protein ID WP_003417282.1
Coordinates 3675578..3676006 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag BCGMEX_RS17305 Protein ID WP_003417286.1
Coordinates 3676010..3676252 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCGMEX_RS17275 3671400..3671801 - 402 WP_003417264.1 cytidine deaminase -
BCGMEX_RS17280 3671942..3672376 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
BCGMEX_RS17285 3672373..3672807 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
BCGMEX_RS17290 3672936..3674708 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
BCGMEX_RS17295 3674708..3675499 + 792 WP_010950870.1 succinate dehydrogenase iron-sulfur subunit -
BCGMEX_RS17300 3675578..3676006 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
BCGMEX_RS17305 3676010..3676252 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
BCGMEX_RS17310 3676374..3676988 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
BCGMEX_RS17315 3676985..3677650 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
BCGMEX_RS17320 3677651..3678184 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
BCGMEX_RS17325 3678181..3678555 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
BCGMEX_RS17330 3678652..3679716 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T25928 WP_003417282.1 NC_016804:c3676006-3675578 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T25928 NC_016804:c3676006-3675578 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT25928 WP_003417286.1 NC_016804:c3676252-3676010 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT25928 NC_016804:c3676252-3676010 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References