Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4315664..4316259 Replicon chromosome
Accession NZ_CP104846
Organism Escherichia coli strain DFS.1

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag N7219_RS21250 Protein ID WP_000239579.1
Coordinates 4315664..4316014 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag N7219_RS21255 Protein ID WP_001223208.1
Coordinates 4316008..4316259 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7219_RS21230 (4311110) 4311110..4312132 - 1023 WP_001296689.1 ABC transporter permease -
N7219_RS21235 (4312146) 4312146..4313648 - 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
N7219_RS21240 (4313788) 4313788..4314744 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
N7219_RS21245 (4315054) 4315054..4315584 + 531 WP_000055075.1 inorganic diphosphatase -
N7219_RS21250 (4315664) 4315664..4316014 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
N7219_RS21255 (4316008) 4316008..4316259 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
N7219_RS21260 (4316471) 4316471..4316812 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
N7219_RS21265 (4316815) 4316815..4320594 - 3780 WP_000060945.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T259275 WP_000239579.1 NZ_CP104846:c4316014-4315664 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT259275 WP_001223208.1 NZ_CP104846:c4316259-4316008 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References