Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4120783..4121437 Replicon chromosome
Accession NZ_CP104846
Organism Escherichia coli strain DFS.1

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag N7219_RS20250 Protein ID WP_000244765.1
Coordinates 4120783..4121190 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag N7219_RS20255 Protein ID WP_000354050.1
Coordinates 4121171..4121437 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7219_RS20230 (4116740) 4116740..4118473 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
N7219_RS20235 (4118479) 4118479..4119189 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N7219_RS20240 (4119214) 4119214..4120110 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
N7219_RS20245 (4120222) 4120222..4120743 + 522 WP_001055874.1 flavodoxin FldB -
N7219_RS20250 (4120783) 4120783..4121190 - 408 WP_000244765.1 protein YgfX Toxin
N7219_RS20255 (4121171) 4121171..4121437 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
N7219_RS20260 (4121680) 4121680..4122660 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
N7219_RS20265 (4122737) 4122737..4123396 - 660 WP_000250275.1 hemolysin III family protein -
N7219_RS20270 (4123560) 4123560..4123871 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
N7219_RS20275 (4123916) 4123916..4125349 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T259274 WP_000244765.1 NZ_CP104846:c4121190-4120783 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT259274 WP_000354050.1 NZ_CP104846:c4121437-4121171 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References