Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3186716..3187547 Replicon chromosome
Accession NZ_CP104846
Organism Escherichia coli strain DFS.1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag N7219_RS16050 Protein ID WP_000854815.1
Coordinates 3187173..3187547 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag N7219_RS16045 Protein ID WP_001280918.1
Coordinates 3186716..3187084 (+) Length 123 a.a.

Genomic Context


N7219_RS16000N7219_RS16005N7219_RS16010N7219_RS16015N7219_RS16020N7219_RS16025N7219_RS16030N7219_RS16035N7219_RS16040N7219_RS16045N7219_RS16050N7219_RS16055N7219_RS16060N7219_RS16070N7219_RS16065N7219_RS16075N7219_RS16080N7219_RS16085N7219_RS16090
Location: 3181805..3182551 (747 bp)
Type: Others
Protein ID: WP_001016257.1
Location: 3182634..3182984 (351 bp)
Type: Others
Protein ID: Protein_3144
Location: 3183000..3183410 (411 bp)
Type: Others
Protein ID: WP_000846703.1
Location: 3183631..3184449 (819 bp)
Type: Others
Protein ID: WP_001542275.1
Location: 3184449..3184694 (246 bp)
Type: Others
Protein ID: WP_001164966.1
Location: 3184788..3185261 (474 bp)
Type: Others
Protein ID: WP_001542276.1
Location: 3185277..3185753 (477 bp)
Type: Others
Protein ID: WP_001186200.1
Location: 3185816..3186037 (222 bp)
Type: Others
Protein ID: WP_000692345.1
Location: 3186056..3186700 (645 bp)
Type: Others
Protein ID: WP_000086752.1
Location: 3186716..3187084 (369 bp)
Type: Antitoxin
Protein ID: WP_001280918.1
Location: 3187173..3187547 (375 bp)
Type: Toxin
Protein ID: WP_000854815.1
Location: 3187544..3187738 (195 bp)
Type: Others
Protein ID: WP_000988600.1
Location: 3187784..3187864 (81 bp)
Type: Others
Protein ID: Protein_3155
Location: 3188212..3188535 (324 bp)
Type: Others
Protein ID: WP_225469267.1
Location: 3188153..3188233 (81 bp)
Type: Others
Protein ID: WP_023441679.1
Location: 3188636..3188965 (330 bp)
Type: Others
Protein ID: WP_000450409.1
Location: 3189137..3190195 (1059 bp)
Type: Others
Protein ID: WP_001200889.1
Location: 3190393..3190866 (474 bp)
Type: Others
Protein ID: WP_001105368.1
Location: 3190985..3192151 (1167 bp)
Type: Others
Protein ID: WP_001296209.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N7219_RS16000 (3181805)3181805..3182551+747WP_001016257.1IS21-like element ISEc12 family helper ATPase IstB-
N7219_RS16005 (3182634)3182634..3182984+351Protein_3144hypothetical protein-
N7219_RS16010 (3183000)3183000..3183410+411WP_000846703.1hypothetical protein-
N7219_RS16015 (3183631)3183631..3184449+819WP_001542275.1DUF932 domain-containing protein-
N7219_RS16020 (3184449)3184449..3184694+246WP_001164966.1hypothetical protein-
N7219_RS16025 (3184788)3184788..3185261+474WP_001542276.1antirestriction protein-
N7219_RS16030 (3185277)3185277..3185753+477WP_001186200.1RadC family protein-
N7219_RS16035 (3185816)3185816..3186037+222WP_000692345.1DUF987 domain-containing protein-
N7219_RS16040 (3186056)3186056..3186700+645WP_000086752.1hypothetical protein-
N7219_RS16045 (3186716)3186716..3187084+369WP_001280918.1type IV toxin-antitoxin system YeeU family antitoxinAntitoxin
N7219_RS16050 (3187173)3187173..3187547+375WP_000854815.1type IV toxin-antitoxin system cytoskeleton-binding toxin CbtAToxin
N7219_RS16055 (3187544)3187544..3187738+195WP_000988600.1DUF5983 family protein-
N7219_RS16060 (3187784)3187784..3187864+81Protein_3155hypothetical protein-
N7219_RS16065 (3188153)3188153..3188233-81WP_023441679.1hypothetical protein-
N7219_RS16070 (3188212)3188212..3188535+324WP_225469267.1EutP/PduV family microcompartment system protein-
N7219_RS16075 (3188636)3188636..3188965-330WP_000450409.1DUF496 family protein-
N7219_RS16080 (3189137)3189137..3190195-1059WP_001200889.1FUSC family protein-
N7219_RS16085 (3190393)3190393..3190866-474WP_001105368.1DNA gyrase inhibitor SbmC-
N7219_RS16090 (3190985)3190985..3192151-1167WP_001296209.1serine-type D-Ala-D-Ala carboxypeptidase DacD-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(19-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T259272 WP_000854815.1 NZ_CP104846:3187173-3187547 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp


Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT259272 WP_001280918.1 NZ_CP104846:3186716-3187084 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A066T988


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A061Y7A8

References