Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1455876..1456494 Replicon chromosome
Accession NZ_CP104846
Organism Escherichia coli strain DFS.1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N7219_RS07130 Protein ID WP_001291435.1
Coordinates 1455876..1456094 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N7219_RS07135 Protein ID WP_000344800.1
Coordinates 1456120..1456494 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7219_RS07095 (1451163) 1451163..1451735 + 573 WP_000779831.1 YbaY family lipoprotein -
N7219_RS07100 (1451766) 1451766..1452077 - 312 WP_000409908.1 MGMT family protein -
N7219_RS07110 (1452456) 1452456..1452809 + 354 WP_000878135.1 DUF1428 family protein -
N7219_RS07115 (1452851) 1452851..1454401 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N7219_RS07120 (1454565) 1454565..1455035 - 471 WP_000136192.1 YlaC family protein -
N7219_RS07125 (1455151) 1455151..1455702 - 552 WP_000102539.1 maltose O-acetyltransferase -
N7219_RS07130 (1455876) 1455876..1456094 - 219 WP_001291435.1 HHA domain-containing protein Toxin
N7219_RS07135 (1456120) 1456120..1456494 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N7219_RS07140 (1457040) 1457040..1460189 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
N7219_RS07145 (1460212) 1460212..1461405 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T259261 WP_001291435.1 NZ_CP104846:c1456094-1455876 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT259261 WP_000344800.1 NZ_CP104846:c1456494-1456120 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References