Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3116435..3117122 Replicon chromosome
Accession NC_016804
Organism Mycobacterium bovis BCG str. Mexico

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FBY8
Locus tag BCGMEX_RS14775 Protein ID WP_011799298.1
Coordinates 3116679..3117122 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag BCGMEX_RS14770 Protein ID WP_003414620.1
Coordinates 3116435..3116692 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCGMEX_RS14750 3111755..3112609 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
BCGMEX_RS14755 3112665..3113828 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
BCGMEX_RS14760 3113845..3115059 - 1215 WP_011799297.1 zinc metalloprotease Rip -
BCGMEX_RS14765 3115067..3116308 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
BCGMEX_RS14770 3116435..3116692 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
BCGMEX_RS14775 3116679..3117122 + 444 WP_011799298.1 type II toxin-antitoxin system VapC family toxin Toxin
BCGMEX_RS14780 3117202..3117864 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
BCGMEX_RS14785 3117960..3118151 + 192 WP_003414632.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
BCGMEX_RS14790 3118483..3120231 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
BCGMEX_RS14795 3120327..3120908 + 582 WP_003414644.1 fasciclin domain-containing protein -
BCGMEX_RS14800 3121008..3121274 + 267 WP_031657293.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16625.74 Da        Isoelectric Point: 6.4890

>T25926 WP_011799298.1 NC_016804:3116679-3117122 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDTLLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

>T25926 NC_016804:3116679-3117122 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACACCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT25926 WP_003414620.1 NC_016804:3116435-3116692 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp

>AT25926 NC_016804:3116435-3116692 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBY8

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References