Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/DUF4065(antitoxin) |
| Location | 4642234..4643159 | Replicon | chromosome |
| Accession | NZ_CP104843 | ||
| Organism | Escherichia coli strain DFL.5 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | N7217_RS22580 | Protein ID | WP_014640052.1 |
| Coordinates | 4642234..4642620 (-) | Length | 129 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | - |
| Locus tag | N7217_RS22585 | Protein ID | WP_024174200.1 |
| Coordinates | 4642650..4643159 (-) | Length | 170 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N7217_RS22545 (4637799) | 4637799..4637999 | - | 201 | WP_021527487.1 | YdaS family helix-turn-helix protein | - |
| N7217_RS22550 (4638090) | 4638090..4638764 | + | 675 | WP_021530636.1 | LexA family transcriptional regulator | - |
| N7217_RS22555 (4639432) | 4639432..4639794 | + | 363 | WP_000135680.1 | protein YfdP | - |
| N7217_RS22560 (4639860) | 4639860..4640684 | + | 825 | WP_023908886.1 | DUF2303 family protein | - |
| N7217_RS22565 (4640861) | 4640861..4641655 | + | 795 | WP_261629255.1 | hypothetical protein | - |
| N7217_RS22570 (4641692) | 4641692..4641973 | + | 282 | WP_001093916.1 | pyocin activator PrtN family protein | - |
| N7217_RS22575 (4642021) | 4642021..4642194 | - | 174 | WP_023908888.1 | hypothetical protein | - |
| N7217_RS22580 (4642234) | 4642234..4642620 | - | 387 | WP_014640052.1 | hypothetical protein | Toxin |
| N7217_RS22585 (4642650) | 4642650..4643159 | - | 510 | WP_024174200.1 | Panacea domain-containing protein | Antitoxin |
| N7217_RS22590 (4643476) | 4643476..4643580 | - | 105 | Protein_4426 | tRNA-dihydrouridine synthase | - |
| N7217_RS22595 (4643942) | 4643942..4644946 | - | 1005 | WP_022646425.1 | DUF2713 family protein | - |
| N7217_RS22600 (4645264) | 4645264..4645779 | + | 516 | WP_000416263.1 | zinc uptake transcriptional repressor Zur | - |
| N7217_RS22605 (4645821) | 4645821..4646030 | - | 210 | WP_001296638.1 | CsbD family protein | - |
| N7217_RS22610 (4646146) | 4646146..4647471 | - | 1326 | WP_001361471.1 | MATE family efflux transporter DinF | - |
| N7217_RS22615 (4647544) | 4647544..4648152 | - | 609 | WP_000646078.1 | transcriptional repressor LexA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 129 a.a. Molecular weight: 14465.40 Da Isoelectric Point: 5.4833
>T259249 WP_014640052.1 NZ_CP104843:c4642620-4642234 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE
Download Length: 387 bp
Antitoxin
Download Length: 170 a.a. Molecular weight: 19559.39 Da Isoelectric Point: 5.3338
>AT259249 WP_024174200.1 NZ_CP104843:c4643159-4642650 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS
Download Length: 510 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|