Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4283527..4284359 | Replicon | chromosome |
| Accession | NZ_CP104843 | ||
| Organism | Escherichia coli strain DFL.5 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A0Q2Y5N3 |
| Locus tag | N7217_RS20750 | Protein ID | WP_001514886.1 |
| Coordinates | 4283527..4283901 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1NM52 |
| Locus tag | N7217_RS20755 | Protein ID | WP_001295723.1 |
| Coordinates | 4283991..4284359 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N7217_RS20725 (4281255) | 4281255..4281404 | - | 150 | Protein_4058 | hypothetical protein | - |
| N7217_RS20730 (4281510) | 4281510..4281686 | - | 177 | WP_000839290.1 | DUF957 domain-containing protein | - |
| N7217_RS20735 (4281703) | 4281703..4282065 | - | 363 | Protein_4060 | DUF5983 family protein | - |
| N7217_RS20740 (4282159) | 4282159..4283387 | + | 1229 | WP_164930399.1 | IS3 family transposase | - |
| N7217_RS20745 (4283399) | 4283399..4283530 | - | 132 | Protein_4062 | DUF5983 family protein | - |
| N7217_RS20750 (4283527) | 4283527..4283901 | - | 375 | WP_001514886.1 | TA system toxin CbtA family protein | Toxin |
| N7217_RS20755 (4283991) | 4283991..4284359 | - | 369 | WP_001295723.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| N7217_RS20760 (4284522) | 4284522..4284743 | - | 222 | WP_000692286.1 | DUF987 domain-containing protein | - |
| N7217_RS20765 (4284806) | 4284806..4285282 | - | 477 | WP_001545734.1 | RadC family protein | - |
| N7217_RS20770 (4285298) | 4285298..4285771 | - | 474 | WP_000855059.1 | antirestriction protein | - |
| N7217_RS20775 (4286113) | 4286113..4286931 | - | 819 | WP_001234729.1 | DUF932 domain-containing protein | - |
| N7217_RS20780 (4287049) | 4287049..4287244 | - | 196 | Protein_4069 | DUF905 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13930.91 Da Isoelectric Point: 7.2909
>T259246 WP_001514886.1 NZ_CP104843:c4283901-4283527 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK
Download Length: 375 bp
Antitoxin
Download Length: 123 a.a. Molecular weight: 13592.40 Da Isoelectric Point: 6.6255
>AT259246 WP_001295723.1 NZ_CP104843:c4284359-4283991 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Q2Y5N3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1NM52 |