Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3735955..3736573 Replicon chromosome
Accession NZ_CP104843
Organism Escherichia coli strain DFL.5

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N7217_RS18135 Protein ID WP_001291435.1
Coordinates 3736355..3736573 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N7217_RS18130 Protein ID WP_000344800.1
Coordinates 3735955..3736329 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7217_RS18120 (3731044) 3731044..3732237 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N7217_RS18125 (3732260) 3732260..3735409 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N7217_RS18130 (3735955) 3735955..3736329 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N7217_RS18135 (3736355) 3736355..3736573 + 219 WP_001291435.1 HHA domain-containing protein Toxin
N7217_RS18140 (3736745) 3736745..3737296 + 552 WP_000102574.1 maltose O-acetyltransferase -
N7217_RS18145 (3737412) 3737412..3737882 + 471 WP_022645280.1 YlaC family protein -
N7217_RS18150 (3738046) 3738046..3739596 + 1551 WP_022645279.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N7217_RS18155 (3739638) 3739638..3739991 - 354 WP_000878140.1 DUF1428 domain-containing protein -
N7217_RS18165 (3740370) 3740370..3740681 + 312 WP_000409911.1 MGMT family protein -
N7217_RS18170 (3740712) 3740712..3741284 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T259242 WP_001291435.1 NZ_CP104843:3736355-3736573 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT259242 WP_000344800.1 NZ_CP104843:3735955-3736329 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References