Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3294023..3294728 Replicon chromosome
Accession NZ_CP104843
Organism Escherichia coli strain DFL.5

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag N7217_RS15945 Protein ID WP_000539521.1
Coordinates 3294023..3294409 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag N7217_RS15950 Protein ID WP_001280945.1
Coordinates 3294399..3294728 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7217_RS15925 (3290027) 3290027..3290653 + 627 WP_001295292.1 glutathione S-transferase GstB -
N7217_RS15930 (3290650) 3290650..3291765 - 1116 WP_000554964.1 aldose sugar dehydrogenase YliI -
N7217_RS15935 (3291876) 3291876..3292259 - 384 WP_000497137.1 biofilm formation regulator BssR -
N7217_RS15940 (3292472) 3292472..3293797 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
N7217_RS15945 (3294023) 3294023..3294409 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N7217_RS15950 (3294399) 3294399..3294728 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
N7217_RS15955 (3294798) 3294798..3296126 - 1329 WP_022645414.1 GGDEF domain-containing protein -
N7217_RS15960 (3296134) 3296134..3298482 - 2349 WP_022645413.1 EAL domain-containing protein -
N7217_RS15965 (3298659) 3298659..3299570 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T259240 WP_000539521.1 NZ_CP104843:3294023-3294409 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT259240 WP_001280945.1 NZ_CP104843:3294399-3294728 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References