Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2637429..2638067 Replicon chromosome
Accession NZ_CP104843
Organism Escherichia coli strain DFL.5

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag N7217_RS12720 Protein ID WP_000813794.1
Coordinates 2637891..2638067 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N7217_RS12715 Protein ID WP_001270286.1
Coordinates 2637429..2637845 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7217_RS12695 (2632581) 2632581..2633522 - 942 WP_022645667.1 ABC transporter permease -
N7217_RS12700 (2633523) 2633523..2634536 - 1014 WP_022645666.1 ABC transporter ATP-binding protein -
N7217_RS12705 (2634554) 2634554..2635699 - 1146 WP_000047466.1 ABC transporter substrate-binding protein -
N7217_RS12710 (2635944) 2635944..2637350 - 1407 WP_022645665.1 PLP-dependent aminotransferase family protein -
N7217_RS12715 (2637429) 2637429..2637845 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
N7217_RS12720 (2637891) 2637891..2638067 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
N7217_RS12725 (2638289) 2638289..2638519 + 231 WP_000491567.1 DUF2554 family protein -
N7217_RS12730 (2638611) 2638611..2640572 - 1962 WP_023909195.1 23S rRNA 5-hydroxycytidine C2501 synthase -
N7217_RS12735 (2640645) 2640645..2641181 - 537 WP_000429148.1 DNA-binding transcriptional regulator SutR -
N7217_RS12740 (2641234) 2641234..2642445 + 1212 WP_071788120.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T259238 WP_000813794.1 NZ_CP104843:c2638067-2637891 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT259238 WP_001270286.1 NZ_CP104843:c2637845-2637429 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References