Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 976695..977349 Replicon chromosome
Accession NZ_CP104843
Organism Escherichia coli strain DFL.5

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag N7217_RS04785 Protein ID WP_000244781.1
Coordinates 976942..977349 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N7217_RS04780 Protein ID WP_000354046.1
Coordinates 976695..976961 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7217_RS04760 (972773) 972773..974206 - 1434 WP_022646090.1 6-phospho-beta-glucosidase BglA -
N7217_RS04765 (974251) 974251..974562 + 312 WP_001182953.1 N(4)-acetylcytidine aminohydrolase -
N7217_RS04770 (974726) 974726..975385 + 660 WP_000250269.1 hemolysin III family protein -
N7217_RS04775 (975462) 975462..976442 - 981 WP_000886050.1 tRNA-modifying protein YgfZ -
N7217_RS04780 (976695) 976695..976961 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N7217_RS04785 (976942) 976942..977349 + 408 WP_000244781.1 protein YgfX Toxin
N7217_RS04790 (977389) 977389..977910 - 522 WP_001055874.1 flavodoxin FldB -
N7217_RS04795 (978022) 978022..978918 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
N7217_RS04800 (978943) 978943..979653 + 711 WP_000715222.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N7217_RS04805 (979659) 979659..981392 + 1734 WP_000813233.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T259232 WP_000244781.1 NZ_CP104843:976942-977349 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT259232 WP_000354046.1 NZ_CP104843:976695-976961 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References