Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 200160..201061 Replicon plasmid unnamed5
Accession NZ_CP104841
Organism Enterobacter cloacae strain 2022CK-00409

Toxin (Protein)


Gene name - Uniprot ID A0A837LJP8
Locus tag N7S94_RS27115 Protein ID WP_007372300.1
Coordinates 200603..201061 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag N7S94_RS27110 Protein ID WP_008786588.1
Coordinates 200160..200606 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7S94_RS27085 (N7S94_27080) 197606..197770 - 165 WP_007372306.1 hypothetical protein -
N7S94_RS27090 (N7S94_27085) 198057..198500 - 444 WP_007372305.1 hypothetical protein -
N7S94_RS27095 (N7S94_27090) 198560..198838 - 279 WP_007372304.1 hypothetical protein -
N7S94_RS27100 (N7S94_27095) 198810..199652 - 843 WP_007372303.1 hypothetical protein -
N7S94_RS27105 (N7S94_27100) 199694..200011 - 318 WP_007372302.1 hypothetical protein -
N7S94_RS27110 (N7S94_27105) 200160..200606 + 447 WP_008786588.1 DUF2384 domain-containing protein Antitoxin
N7S94_RS27115 (N7S94_27110) 200603..201061 + 459 WP_007372300.1 RES family NAD+ phosphorylase Toxin
N7S94_RS27120 (N7S94_27115) 201105..201335 + 231 WP_007372299.1 hypothetical protein -
N7S94_RS27125 (N7S94_27120) 201403..201669 - 267 WP_007372298.1 hypothetical protein -
N7S94_RS27130 (N7S94_27125) 201719..202273 - 555 WP_007372297.1 hypothetical protein -
N7S94_RS27135 (N7S94_27130) 202432..202773 - 342 WP_007372296.1 hypothetical protein -
N7S94_RS27140 (N7S94_27135) 202892..203335 - 444 WP_007372295.1 hypothetical protein -
N7S94_RS27145 (N7S94_27140) 203573..203911 + 339 WP_007372294.1 hypothetical protein -
N7S94_RS27150 (N7S94_27145) 204274..204600 - 327 WP_007372293.1 hypothetical protein -
N7S94_RS27155 (N7S94_27150) 204684..205082 - 399 WP_007372292.1 hypothetical protein -
N7S94_RS27160 (N7S94_27155) 205093..205380 - 288 WP_016241556.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..318750 318750
- flank IS/Tn - - 195974..197116 1142


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(95-145)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16975.40 Da        Isoelectric Point: 4.5730

>T259226 WP_007372300.1 NZ_CP104841:200603-201061 [Enterobacter cloacae]
VILYRLTKTRYLMTAWSGLGAKEAGGRWNSVGTAMVYLSETASLTMLETLVHIHAPQLLDDFTLLSLDVPDDQIQTFDMS
RLPDNWASEDAPAELALYGDNWAESGSSIALRIPSALSPVEFNYLLNPAHPELFDLMATVKKIPFRFDSRLK

Download         Length: 459 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16689.02 Da        Isoelectric Point: 6.9812

>AT259226 WP_008786588.1 NZ_CP104841:200160-200606 [Enterobacter cloacae]
MTMKVFSPDVTKTNQHCLWQVAGLDNDGIALMDKINHGLDGTVAKHISEWANITPSELRKMSGIPNTTFNRSIKDRFTAD
QSERLVRIIRVIERAVELFEGDKEAAHKWLNEANRGLSWKSPAELVSSETGALEVMRLITRIEHGVYS

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837LJP8

Antitoxin

Source ID Structure

References