Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2941575..2942191 Replicon chromosome
Accession NZ_CP104836
Organism Enterobacter cloacae strain 2022CK-00409

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N7S94_RS14460 Protein ID WP_080292722.1
Coordinates 2941575..2941946 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag N7S94_RS14465 Protein ID WP_213382961.1
Coordinates 2941949..2942191 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7S94_RS14445 (N7S94_14440) 2939075..2939977 + 903 WP_014833793.1 formate dehydrogenase subunit beta -
N7S94_RS14450 (N7S94_14445) 2939974..2940609 + 636 WP_013099357.1 formate dehydrogenase cytochrome b556 subunit -
N7S94_RS14455 (N7S94_14450) 2940606..2941535 + 930 WP_029882351.1 formate dehydrogenase accessory protein FdhE -
N7S94_RS14460 (N7S94_14455) 2941575..2941946 - 372 WP_080292722.1 type II toxin-antitoxin system VapC family toxin Toxin
N7S94_RS14465 (N7S94_14460) 2941949..2942191 - 243 WP_213382961.1 ribbon-helix-helix protein, CopG family Antitoxin
N7S94_RS14470 (N7S94_14465) 2942740..2944227 + 1488 WP_024191381.1 group II intron reverse transcriptase/maturase -
N7S94_RS14475 (N7S94_14470) 2944300..2945109 + 810 WP_261658696.1 alpha/beta hydrolase -
N7S94_RS14480 (N7S94_14475) 2945158..2945565 + 408 WP_048242260.1 transposase -
N7S94_RS14485 (N7S94_14480) 2945562..2945912 + 351 WP_021567584.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13625.69 Da        Isoelectric Point: 6.6407

>T259220 WP_080292722.1 NZ_CP104836:c2941946-2941575 [Enterobacter cloacae]
VNNMAVFDTNILIDLFNNRVEAADAIDHAASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFSGIDEVVTPYQL

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9379.72 Da        Isoelectric Point: 4.4076

>AT259220 WP_213382961.1 NZ_CP104836:c2942191-2941949 [Enterobacter cloacae]
MSVLAELDMGRILIDLPDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRAALGLWGDKKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References