Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2327124..2327640 Replicon chromosome
Accession NZ_CP104836
Organism Enterobacter cloacae strain 2022CK-00409

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag N7S94_RS11510 Protein ID WP_178328142.1
Coordinates 2327124..2327408 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag N7S94_RS11515 Protein ID WP_008501400.1
Coordinates 2327398..2327640 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7S94_RS11495 (N7S94_11490) 2322378..2324021 + 1644 WP_261659351.1 alpha,alpha-phosphotrehalase -
N7S94_RS11500 (N7S94_11495) 2324395..2326533 + 2139 WP_013095357.1 anaerobic ribonucleoside-triphosphate reductase -
N7S94_RS11505 (N7S94_11500) 2326656..2327120 + 465 WP_058683233.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N7S94_RS11510 (N7S94_11505) 2327124..2327408 - 285 WP_178328142.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N7S94_RS11515 (N7S94_11510) 2327398..2327640 - 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N7S94_RS11520 (N7S94_11515) 2327718..2329628 - 1911 WP_178328141.1 PRD domain-containing protein -
N7S94_RS11525 (N7S94_11520) 2329648..2330784 - 1137 WP_261659352.1 lactonase family protein -
N7S94_RS11530 (N7S94_11525) 2330899..2331639 - 741 WP_178328139.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10944.80 Da        Isoelectric Point: 10.4610

>T259218 WP_178328142.1 NZ_CP104836:c2327408-2327124 [Enterobacter cloacae]
MTYELEFDPRALKEWSKLGETVKKQFRKKLAGVLVNPRIESARLHNLPDCYKIKLRSQGYRLVYQVQDNVVTVVVVAIGK
REKSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT259218 WP_008501400.1 NZ_CP104836:c2327640-2327398 [Enterobacter cloacae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References