Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2243307..2244061 Replicon chromosome
Accession NZ_CP104836
Organism Enterobacter cloacae strain 2022CK-00409

Toxin (Protein)


Gene name yeeV Uniprot ID A0A6L5EGB6
Locus tag N7S94_RS11070 Protein ID WP_032669201.1
Coordinates 2243307..2243684 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag N7S94_RS11075 Protein ID WP_074143921.1
Coordinates 2243735..2244061 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7S94_RS11040 (N7S94_11035) 2238915..2240762 + 1848 WP_013098777.1 RNA polymerase sigma factor RpoD -
N7S94_RS11045 (N7S94_11040) 2240864..2241370 - 507 WP_261659342.1 G/U mismatch-specific DNA glycosylase -
N7S94_RS11055 (N7S94_11050) 2241674..2242522 - 849 WP_261659343.1 DUF4942 domain-containing protein -
N7S94_RS11060 (N7S94_11055) 2242586..2242789 - 204 WP_032669203.1 DUF957 domain-containing protein -
N7S94_RS11065 (N7S94_11060) 2242819..2243310 - 492 WP_032672023.1 DUF5983 family protein -
N7S94_RS11070 (N7S94_11065) 2243307..2243684 - 378 WP_032669201.1 TA system toxin CbtA family protein Toxin
N7S94_RS11075 (N7S94_11070) 2243735..2244061 - 327 WP_074143921.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
N7S94_RS11080 (N7S94_11075) 2244118..2244339 - 222 WP_023567997.1 DUF987 domain-containing protein -
N7S94_RS11085 (N7S94_11080) 2244360..2244548 - 189 Protein_2177 Mov34/MPN/PAD-1 family protein -
N7S94_RS11090 (N7S94_11085) 2244611..2245315 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
N7S94_RS11095 (N7S94_11090) 2245472..2247061 - 1590 WP_023327681.1 methyl-accepting chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2229035..2254980 25945


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14157.93 Da        Isoelectric Point: 6.2236

>T259217 WP_032669201.1 NZ_CP104836:c2243684-2243307 [Enterobacter cloacae]
MQTQPLSSTQEATPRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLSSIDILRARKATGLMTRNDYRTVTDITTGKYREVQP

Download         Length: 378 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11953.71 Da        Isoelectric Point: 6.8397

>AT259217 WP_074143921.1 NZ_CP104836:c2244061-2243735 [Enterobacter cloacae]
ITEPWWGLKRSITPCFGARLVQAGNRLHYLADRANITGQFSDADLRYLDQAFPLLLKQLELMLTSGELNPCHQHCVTLYA
KGLTCEADSLGSHGYVYLAIYPTPAATA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L5EGB6

Antitoxin

Source ID Structure

References