Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2045623..2046283 Replicon chromosome
Accession NZ_CP104836
Organism Enterobacter cloacae strain 2022CK-00409

Toxin (Protein)


Gene name cptA Uniprot ID A0A5E1AGQ2
Locus tag N7S94_RS10115 Protein ID WP_023620447.1
Coordinates 2045623..2046036 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag N7S94_RS10120 Protein ID WP_261659322.1
Coordinates 2046017..2046283 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7S94_RS10095 (N7S94_10090) 2041616..2043349 - 1734 WP_178328238.1 single-stranded-DNA-specific exonuclease RecJ -
N7S94_RS10100 (N7S94_10095) 2043355..2044068 - 714 WP_129327561.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N7S94_RS10105 (N7S94_10100) 2044097..2044993 - 897 WP_178328239.1 site-specific tyrosine recombinase XerD -
N7S94_RS10110 (N7S94_10105) 2045095..2045616 + 522 WP_013098613.1 flavodoxin FldB -
N7S94_RS10115 (N7S94_10110) 2045623..2046036 - 414 WP_023620447.1 protein YgfX Toxin
N7S94_RS10120 (N7S94_10115) 2046017..2046283 - 267 WP_261659322.1 FAD assembly factor SdhE Antitoxin
N7S94_RS10125 (N7S94_10120) 2046578..2047558 + 981 WP_178328241.1 tRNA-modifying protein YgfZ -
N7S94_RS10130 (N7S94_10125) 2047668..2048327 - 660 WP_003863433.1 hemolysin III family protein -
N7S94_RS10135 (N7S94_10130) 2048593..2049324 + 732 WP_020687085.1 MurR/RpiR family transcriptional regulator -
N7S94_RS10140 (N7S94_10135) 2049441..2050874 + 1434 WP_178328242.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16220.21 Da        Isoelectric Point: 10.9554

>T259216 WP_023620447.1 NZ_CP104836:c2046036-2045623 [Enterobacter cloacae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLSSGMMLRLRQVGGGKCQHLWLAADSMDIAEWRELRRMLLQQQPTQE

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.02 Da        Isoelectric Point: 4.8432

>AT259216 WP_261659322.1 NZ_CP104836:c2046283-2046017 [Enterobacter cloacae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDEDKLLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1AGQ2

Antitoxin

Source ID Structure

References