Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 1353605..1355388 Replicon chromosome
Accession NZ_CP104836
Organism Enterobacter cloacae strain 2022CK-00409

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N7S94_RS06870 Protein ID WP_178327526.1
Coordinates 1353605..1354954 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N7S94_RS06875 Protein ID WP_178327527.1
Coordinates 1354951..1355388 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7S94_RS06845 (N7S94_06840) 1349425..1350357 - 933 WP_013097946.1 tRNA dihydrouridine(16) synthase DusC -
N7S94_RS06850 (N7S94_06845) 1350525..1350923 + 399 WP_023619766.1 CidA/LrgA family protein -
N7S94_RS06855 (N7S94_06850) 1350920..1351615 + 696 WP_013097948.1 CidB/LrgB family autolysis modulator -
N7S94_RS06860 (N7S94_06855) 1351745..1352629 + 885 WP_178327524.1 cytidine deaminase -
N7S94_RS06865 (N7S94_06860) 1352757..1353470 + 714 WP_178327525.1 outer membrane permeability protein SanA -
N7S94_RS06870 (N7S94_06865) 1353605..1354954 + 1350 WP_178327526.1 HipA domain-containing protein Toxin
N7S94_RS06875 (N7S94_06870) 1354951..1355388 + 438 WP_178327527.1 helix-turn-helix transcriptional regulator Antitoxin
N7S94_RS06880 (N7S94_06875) 1355440..1356450 - 1011 WP_013097952.1 galactose/methyl galactoside ABC transporter permease MglC -
N7S94_RS06885 (N7S94_06880) 1356466..1357986 - 1521 WP_029883073.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
N7S94_RS06890 (N7S94_06885) 1358067..1359065 - 999 WP_014832691.1 galactose/glucose ABC transporter substrate-binding protein MglB -
N7S94_RS06895 (N7S94_06890) 1359361..1360383 - 1023 WP_058680889.1 HTH-type transcriptional regulator GalS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-404)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51179.72 Da        Isoelectric Point: 4.5348

>T259215 WP_178327526.1 NZ_CP104836:1353605-1354954 [Enterobacter cloacae]
METLTVQAYLNETWTDIALIKYPGSENNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDQGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNEFARTKTFTVSDVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVDTMR
LEEGSHYPSLWLPRFDIVRNEQDQLIRLGMESVYSLLQKAPGTLLDHEATLRALINKITSSHMVQQQGYQFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENHIMLSPIYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNAIAQALAEWIPPTT
LLDALHDTAVQLIELPERLEARGVPDQIMEMPAIGFRYIPNKLSRWGLL

Download         Length: 1350 bp

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16168.67 Da        Isoelectric Point: 10.8665

>AT259215 WP_178327527.1 NZ_CP104836:1354951-1355388 [Enterobacter cloacae]
MKISNKSESELLQTLARVRSVNEKRRHDEDGDPDKSSVVKRQRVSSGLTRISTLHRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGMKQDEYAKLVSVSRKTLSDVENGRGNYSADIINKIFKPFGLQTGLVPISKSLIASLFT

Download         Length: 438 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References