Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 5954032..5955548 Replicon chromosome
Accession NZ_CP104835
Organism Achromobacter xylosoxidans strain 2021CK-01139

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag N4T34_RS27580 Protein ID WP_049058967.1
Coordinates 5954032..5955294 (-) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag N4T34_RS27585 Protein ID WP_020926185.1
Coordinates 5955291..5955548 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4T34_RS27570 (N4T34_27595) 5950448..5952631 + 2184 WP_054482530.1 TonB-dependent siderophore receptor -
N4T34_RS27575 (N4T34_27600) 5952635..5953834 - 1200 WP_006385726.1 MFS transporter -
N4T34_RS27580 (N4T34_27605) 5954032..5955294 - 1263 WP_049058967.1 type II toxin-antitoxin system HipA family toxin Toxin
N4T34_RS27585 (N4T34_27610) 5955291..5955548 - 258 WP_020926185.1 type II toxin-antitoxin system Y4mF family antitoxin Antitoxin
N4T34_RS27590 (N4T34_27615) 5955812..5957701 - 1890 WP_054482529.1 molecular chaperone HtpG -
N4T34_RS27595 (N4T34_27620) 5957903..5959306 - 1404 WP_054482573.1 DKNYY domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - adeG 5916375..6140825 224450


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-75)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 45607.99 Da        Isoelectric Point: 7.0531

>T259210 WP_049058967.1 NZ_CP104835:c5955294-5954032 [Achromobacter xylosoxidans]
MSTDALDLYQADRKVGRLFDERPLRFVYDDAWLGWPAAHAIAPDIPLRDGAHVGEAVHAFFENLLPEGRLRRFLQVSRHA
TTVFGLLRSVGGDTASGLTIWPQGERPAPPRYRGTTWGEIVARLQDPAQPALVAENADGARISLAGAQDKLLLMVMPDGS
PAWPEGAAPSTHILKPDIRGFDGVWSSALNETLVMQLAARLGLGVAEAGLQPDTRACLVTRYDRAPDGAGGLLRLHQLDL
CQLAGKSSDVKYEADGGPSLAHCRELLRGMGINAADLKRFLQWVLFNLCVGNNDSHAKNLSVLQTPDGQYRLAPFYDLMC
TALYPGLARNFAFAVGGESRPGHIGRGHLDAMARELGFSPRYVAGMAQALVTELPSALETVQADLARQAMAGTESTLVER
LGQWIRANTRKHAKRWELAG

Download         Length: 1263 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9117.63 Da        Isoelectric Point: 8.8566

>AT259210 WP_020926185.1 NZ_CP104835:c5955548-5955291 [Achromobacter xylosoxidans]
MPSLSTADGLPIVIHTSAELGELVKDVRRAQGLLQTDLAGLSGTGNRFVVDLERGKPTLQLQKVLDMLDLLGLEVRVGPK
RVGRS

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References