Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 5319749..5320313 Replicon chromosome
Accession NZ_CP104835
Organism Achromobacter xylosoxidans strain 2021CK-01139

Toxin (Protein)


Gene name relE Uniprot ID A0A0D6IHV7
Locus tag N4T34_RS24685 Protein ID WP_020926667.1
Coordinates 5319749..5320030 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D6IHW1
Locus tag N4T34_RS24690 Protein ID WP_020926666.1
Coordinates 5320017..5320313 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4T34_RS24660 (N4T34_24685) 5314780..5315283 - 504 WP_006386642.1 flavin reductase family protein -
N4T34_RS24665 (N4T34_24690) 5315307..5316320 - 1014 WP_049051052.1 LLM class flavin-dependent oxidoreductase -
N4T34_RS24670 (N4T34_24695) 5316442..5317275 + 834 WP_054483102.1 IclR family transcriptional regulator -
N4T34_RS24675 (N4T34_24700) 5317511..5318566 + 1056 WP_054483104.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
N4T34_RS24680 (N4T34_24705) 5318563..5319699 + 1137 WP_054483106.1 tRNA guanosine(34) transglycosylase Tgt -
N4T34_RS24685 (N4T34_24710) 5319749..5320030 - 282 WP_020926667.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4T34_RS24690 (N4T34_24715) 5320017..5320313 - 297 WP_020926666.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N4T34_RS24695 (N4T34_24720) 5320686..5321030 + 345 WP_006386647.1 preprotein translocase subunit YajC -
N4T34_RS24700 (N4T34_24725) 5321146..5323026 + 1881 WP_006386648.1 protein translocase subunit SecD -
N4T34_RS24705 (N4T34_24730) 5323078..5324013 + 936 WP_006386649.1 protein translocase subunit SecF -
N4T34_RS24710 (N4T34_24735) 5324179..5324550 + 372 WP_054483108.1 type II toxin-antitoxin system RelE/ParE family toxin -
N4T34_RS24715 (N4T34_24740) 5324547..5324858 + 312 WP_006386651.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-52)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10262.77 Da        Isoelectric Point: 7.0080

>T259209 WP_020926667.1 NZ_CP104835:c5320030-5319749 [Achromobacter xylosoxidans]
VPAVEWSSAARADLLAIVDYISDDNPDAAQRLKDDIETKAAQLPARPALYRPGRIAGTREMVVRANYIIVYAADALAVRI
LRILHAAQQWPPQ

Download         Length: 282 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10717.24 Da        Isoelectric Point: 7.3208

>AT259209 WP_020926666.1 NZ_CP104835:c5320313-5320017 [Achromobacter xylosoxidans]
MPQTSMLHVRVDDKLKADATEKLAEFGLTISDAVRILLTRVAKEGGLPAGLTTDAQAHDAWFRAKVQEALADTGPAVPHQ
QVMDEAQALIDRKRRARS

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6IHV7

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6IHW1

References