Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 2701046..2701726 Replicon chromosome
Accession NZ_CP104835
Organism Achromobacter xylosoxidans strain 2021CK-01139

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag N4T34_RS12915 Protein ID WP_006386381.1
Coordinates 2701046..2701231 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N4T34_RS12920 Protein ID WP_006386380.1
Coordinates 2701307..2701726 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4T34_RS12905 (N4T34_12910) 2697185..2698588 + 1404 WP_054482410.1 dihydrolipoyl dehydrogenase -
N4T34_RS12910 (N4T34_12915) 2698760..2700799 - 2040 WP_054482409.1 PEP/pyruvate-binding domain-containing protein -
N4T34_RS12915 (N4T34_12920) 2701046..2701231 + 186 WP_006386381.1 type II toxin-antitoxin system HicA family toxin Toxin
N4T34_RS12920 (N4T34_12925) 2701307..2701726 + 420 WP_006386380.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N4T34_RS12925 (N4T34_12930) 2701817..2703235 - 1419 WP_054482408.1 argininosuccinate lyase -
N4T34_RS12930 (N4T34_12935) 2703448..2704779 + 1332 WP_054482498.1 mechanosensitive ion channel -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-94)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7058.16 Da        Isoelectric Point: 10.6654

>T259208 WP_006386381.1 NZ_CP104835:2701046-2701231 [Achromobacter xylosoxidans]
MKYSEFKKWLERQGAVFVAHRSGSSHFRVTLNGATTIFPYHGSKEMGKHLEHEIKKQLGLK

Download         Length: 186 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15506.81 Da        Isoelectric Point: 4.9597

>AT259208 WP_006386380.1 NZ_CP104835:2701307-2701726 [Achromobacter xylosoxidans]
MLTYPFTLTLDSNRTWLVRFPDIPEALTVGDDEQEAAINAREALEAALEIYFDARRPIPLPSPVSAGQASVTLPALITSK
VFLSNEMIQQGVRKAELARRMGVHMPQVDRLLDVRHASRIEQVESALEQLGRRLEVSLA

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References