259207

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 1286107..1287149 Replicon chromosome
Accession NZ_CP104835
Organism Achromobacter xylosoxidans strain 2021CK-01139

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag N4T34_RS06210 Protein ID WP_003109777.1
Coordinates 1286107..1286682 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag N4T34_RS06215 Protein ID WP_003050245.1
Coordinates 1286679..1287149 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4T34_RS06185 (N4T34_06190) 1282545..1283270 - 726 WP_003050273.1 CBASS effector endonuclease NucC -
N4T34_RS06190 (N4T34_06195) 1283309..1284211 - 903 WP_003105624.1 CBASS oligonucleotide cyclase -
N4T34_RS06195 (N4T34_06200) 1284211..1284711 - 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
N4T34_RS06200 (N4T34_06205) 1284708..1285178 - 471 WP_003105626.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
N4T34_RS06205 (N4T34_06210) 1285175..1286089 - 915 WP_003105629.1 AAA family ATPase -
N4T34_RS06210 (N4T34_06215) 1286107..1286682 - 576 WP_003109777.1 PIN domain-containing protein Toxin
N4T34_RS06215 (N4T34_06220) 1286679..1287149 - 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
N4T34_RS06220 (N4T34_06225) 1287353..1287736 + 384 WP_003105635.1 RAQPRD family integrative conjugative element protein -
N4T34_RS06225 (N4T34_06230) 1287733..1287966 + 234 WP_003050225.1 TIGR03758 family integrating conjugative element protein -
N4T34_RS06230 (N4T34_06235) 1287983..1288342 + 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
N4T34_RS06235 (N4T34_06240) 1288354..1288752 + 399 WP_003105639.1 TIGR03750 family conjugal transfer protein -
N4T34_RS06240 (N4T34_06245) 1288749..1289441 + 693 WP_054480731.1 TIGR03746 family integrating conjugative element protein -
N4T34_RS06245 (N4T34_06250) 1289438..1290349 + 912 WP_003105643.1 TIGR03749 family integrating conjugative element protein -
N4T34_RS06250 (N4T34_06255) 1290339..1291757 + 1419 WP_003109776.1 TIGR03752 family integrating conjugative element protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1237298..1335044 97746


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21644.79 Da        Isoelectric Point: 5.6172

>T259207 WP_003109777.1 NZ_CP104835:c1286682-1286107 [Achromobacter xylosoxidans]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIEVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT259207 WP_003050245.1 NZ_CP104835:c1287149-1286679 [Achromobacter xylosoxidans]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References