Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1178954..1179527 Replicon chromosome
Accession NZ_CP104835
Organism Achromobacter xylosoxidans strain 2021CK-01139

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N4T34_RS05645 Protein ID WP_049054629.1
Coordinates 1179150..1179527 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag N4T34_RS05640 Protein ID WP_054471260.1
Coordinates 1178954..1179163 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4T34_RS05620 (N4T34_05625) 1174360..1175148 - 789 WP_049054627.1 helix-turn-helix transcriptional regulator -
N4T34_RS05625 (N4T34_05630) 1175247..1176173 + 927 WP_020924995.1 DMT family transporter -
N4T34_RS05630 (N4T34_05635) 1176186..1177004 - 819 WP_054480704.1 AAC(3) family N-acetyltransferase -
N4T34_RS05635 (N4T34_05640) 1177156..1178829 + 1674 WP_054480706.1 energy-dependent translational throttle protein EttA -
N4T34_RS05640 (N4T34_05645) 1178954..1179163 + 210 WP_054471260.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
N4T34_RS05645 (N4T34_05650) 1179150..1179527 + 378 WP_049054629.1 type II toxin-antitoxin system VapC family toxin Toxin
N4T34_RS05650 (N4T34_05655) 1179595..1180128 + 534 WP_054480708.1 isochorismatase family protein -
N4T34_RS05655 (N4T34_05660) 1180319..1180543 + 225 WP_006388976.1 glycine zipper 2TM domain-containing protein -
N4T34_RS05660 (N4T34_05665) 1180673..1180930 - 258 WP_006388977.1 cell division topological specificity factor MinE -
N4T34_RS05665 (N4T34_05670) 1180934..1181749 - 816 WP_006388978.1 septum site-determining protein MinD -
N4T34_RS05670 (N4T34_05675) 1181938..1182855 - 918 WP_054439442.1 septum site-determining protein MinC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13846.11 Da        Isoelectric Point: 6.3721

>T259206 WP_049054629.1 NZ_CP104835:1179150-1179527 [Achromobacter xylosoxidans]
MILVDTSIWIDHLSDGEPCLVRLLEEESVLMHPFIAGELALGSLGRRDVVLGAMSLLPQVVRASHDEVMHFLHSERLFGK
GIGYVDLHLLASTRLTPGAALWTRDKRLQALATTLSLAVDPPRYH

Download         Length: 378 bp

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7521.62 Da        Isoelectric Point: 9.9435

>AT259206 WP_054471260.1 NZ_CP104835:1178954-1179163 [Achromobacter xylosoxidans]
VRTTVTLDDDLLELARTYTGVQETSALVTRALTQLVQKEAAKRLAKLGGSSPKLKPIPRRQTETCNDPG

Download         Length: 210 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References