Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5220730..5221355 Replicon chromosome
Accession NZ_CP104796
Organism Klebsiella pneumoniae strain GX34

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N7T97_RS26320 Protein ID WP_040182550.1
Coordinates 5220730..5221113 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag N7T97_RS26325 Protein ID WP_004150355.1
Coordinates 5221113..5221355 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7T97_RS26305 (5218096) 5218096..5218998 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
N7T97_RS26310 (5218995) 5218995..5219630 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
N7T97_RS26315 (5219627) 5219627..5220556 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
N7T97_RS26320 (5220730) 5220730..5221113 - 384 WP_040182550.1 type II toxin-antitoxin system VapC family toxin Toxin
N7T97_RS26325 (5221113) 5221113..5221355 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
N7T97_RS26330 (5221560) 5221560..5222477 + 918 WP_023302328.1 alpha/beta hydrolase -
N7T97_RS26335 (5222491) 5222491..5223432 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
N7T97_RS26340 (5223477) 5223477..5223914 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
N7T97_RS26345 (5223911) 5223911..5224771 - 861 WP_004146232.1 virulence factor BrkB family protein -
N7T97_RS26350 (5224765) 5224765..5225364 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14376.67 Da        Isoelectric Point: 9.5352

>T259201 WP_040182550.1 NZ_CP104796:c5221113-5220730 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLKLITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT259201 WP_004150355.1 NZ_CP104796:c5221355-5221113 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References