Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4697768..4698284 Replicon chromosome
Accession NZ_CP104796
Organism Klebsiella pneumoniae strain GX34

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag N7T97_RS23695 Protein ID WP_002886902.1
Coordinates 4697768..4698052 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag N7T97_RS23700 Protein ID WP_002886901.1
Coordinates 4698042..4698284 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7T97_RS23670 (4693184) 4693184..4693492 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
N7T97_RS23675 (4693577) 4693577..4693750 + 174 WP_032410138.1 hypothetical protein -
N7T97_RS23680 (4693753) 4693753..4694496 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
N7T97_RS23685 (4694853) 4694853..4696991 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
N7T97_RS23690 (4697300) 4697300..4697764 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N7T97_RS23695 (4697768) 4697768..4698052 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N7T97_RS23700 (4698042) 4698042..4698284 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N7T97_RS23705 (4698362) 4698362..4700272 - 1911 WP_009486549.1 PRD domain-containing protein -
N7T97_RS23710 (4700295) 4700295..4701449 - 1155 WP_023302389.1 lactonase family protein -
N7T97_RS23715 (4701516) 4701516..4702256 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T259199 WP_002886902.1 NZ_CP104796:c4698052-4697768 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT259199 WP_002886901.1 NZ_CP104796:c4698284-4698042 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References