Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4612484..4613294 Replicon chromosome
Accession NZ_CP104796
Organism Klebsiella pneumoniae strain GX34

Toxin (Protein)


Gene name KacT Uniprot ID A0A332NV98
Locus tag N7T97_RS23315 Protein ID WP_014908042.1
Coordinates 4612484..4613017 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag N7T97_RS23320 Protein ID WP_023343051.1
Coordinates 4613028..4613294 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7T97_RS23310 (4611315) 4611315..4612436 + 1122 WP_012737335.1 cupin domain-containing protein -
N7T97_RS23315 (4612484) 4612484..4613017 - 534 WP_014908042.1 type II toxin-antitoxin system toxin KacT Toxin
N7T97_RS23320 (4613028) 4613028..4613294 - 267 WP_023343051.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
N7T97_RS23325 (4613397) 4613397..4614830 - 1434 WP_023343050.1 Cu(+)/Ag(+) sensor histidine kinase -
N7T97_RS23330 (4614820) 4614820..4615503 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
N7T97_RS23335 (4615676) 4615676..4617061 + 1386 WP_040182471.1 efflux transporter outer membrane subunit -
N7T97_RS23340 (4617079) 4617079..4617423 + 345 WP_004192220.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19795.68 Da        Isoelectric Point: 5.2614

>T259198 WP_014908042.1 NZ_CP104796:c4613017-4612484 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGLGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10021.46 Da        Isoelectric Point: 10.5807

>AT259198 WP_023343051.1 NZ_CP104796:c4613294-4613028 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRRVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332NV98

Antitoxin

Source ID Structure

References